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Quitting Smoking clinical trials recruiting in the U.S.

75 studies for Quitting Smoking are recruiting participants at sites across the United States.

Quitting smoking is important for your health. Tobacco use is the most common preventable cause of death. Find the best way for you to quit.

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Recently updated studies

Rural Smoking Cessation

RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Nov 13, 2026 · NCT06584929

My Path to Quit Tobacco

RecruitingPhase 4Healthy volunteers welcome
Ages 21 and older · All sexes · Updated Nov 10, 2026 · NCT07419425

Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation

RecruitingPhase 2Healthy volunteers welcomeMentions payment for participants
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07099638

Optimizing Medications and Lung Health in People With HIV Through Pharmacist-led Proactive E-Consults

Recruiting
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07507435

Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Nov 6, 2026 · NCT07766655

Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors

Recruiting
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT05687604

Personalized Tobacco Treatment in Primary Care (MOTIVATE)

Recruiting
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT05846841

Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients

Recruiting
Ages 18 to 89 · All sexes · Updated Oct 23, 2026 · NCT07166120

Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT01776398

Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily

Recruiting
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT07425119

Testing the mHealth App Intervention for Nondaily Smokers "SiS4"

Recruiting
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT06678243

The Avenues Study: Dual Use Cessation

RecruitingPhase 4
Ages 21 and older · All sexes · Updated Oct 7, 2026 · NCT06474299

Smoking Cessation Pharmacotherapy-Nurse Practitioner Led Tobacco Treatment Team Study

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05733767

Quitting Matters Human Immunodeficiency Virus Hybrid Trial

Recruiting
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06883097

Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain

Recruiting
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06442514

A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation

RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07487818

Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos

Recruiting
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT06926608

Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)

Recruiting
Ages 22 to 65 · All sexes · Updated Sep 16, 2026 · NCT05276050

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Sep 15, 2026 · NCT07145866

Modulating Neural Mechanisms of Reward Processing in Tobacco Users

Recruiting
Ages 18 to 60 · All sexes · Updated Sep 10, 2026 · NCT07812753

Trauma-Informed Care for Smoking Cessation for Pregnancy

RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Sep 10, 2026 · NCT07129590

Overcoming Nicotine Dependence to Enable Quitting

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05513872

Vaped Phenanthrene

RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Sep 3, 2026 · NCT07134426

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.