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Quitting Smoking clinical trials recruiting in the U.S.

74 studies for Quitting Smoking are recruiting participants at sites across the United States.

Quitting smoking is important for your health. Tobacco use is the most common preventable cause of death. Find the best way for you to quit.

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Recently updated studies

Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain

Recruiting
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06442514

A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation

RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07487818

Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos

Recruiting
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT06926608

Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)

Recruiting
Ages 22 to 65 · All sexes · Updated Sep 16, 2026 · NCT05276050

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Sep 15, 2026 · NCT07145866

Modulating Neural Mechanisms of Reward Processing in Tobacco Users

Recruiting
Ages 18 to 60 · All sexes · Updated Sep 10, 2026 · NCT07812753

Trauma-Informed Care for Smoking Cessation for Pregnancy

RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Sep 10, 2026 · NCT07129590

Overcoming Nicotine Dependence to Enable Quitting

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05513872

Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 8, 2026 · NCT07766655

Vaped Phenanthrene

RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Sep 3, 2026 · NCT07134426

A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT06693700

Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Aug 20, 2026 · NCT06678789

Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation

RecruitingPhase 2Healthy volunteers welcomeMentions payment for participants
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07099638

Evaluating the Impact of CONNECT in a Multilingual Population

RecruitingHealthy volunteers welcome
Ages 50 to 80 · All sexes · Updated Aug 13, 2026 · NCT07111936

Family-Based Financial Incentives Intervention for Smoking Cessation

Recruiting
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06556433

Personalized Brain Stimulation to Help Veterans Quit Smoking

Recruiting
Ages 18 to 70 · All sexes · Updated Aug 4, 2026 · NCT07050862

Personalized Tobacco Treatment in Primary Care (MOTIVATE)

Recruiting
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT05846841

Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily

Recruiting
Ages 18 and older · All sexes · Updated Jul 28, 2026 · NCT07425119

Rural Smoking Cessation

RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Jul 27, 2026 · NCT06584929

Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients

Recruiting
Ages 18 to 89 · All sexes · Updated Jul 24, 2026 · NCT07166120

My Path to Quit Tobacco

RecruitingPhase 4Healthy volunteers welcome
Ages 21 and older · All sexes · Updated Jul 23, 2026 · NCT07419425

Multi-Site Trial of Tirzepatide for Smoking Cessation

RecruitingPhase 2
Ages 21 to 65 · All sexes · Updated Jul 17, 2026 · NCT07602699

Enhancing Smoking Cessation for African American People Everywhere

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 13, 2026 · NCT07024992

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.