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The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion

The Effect of Zolpidem on Outcomes Following Lumbar Spine Fusion: A Randomized Control Trial

Who can join

Ages 18 to 75 · All sexes

Inclusion Criteria:

* degenerative lumbar disease
* age of 18-75
* undergoing open primary one- to three-level lumbar fusion

Exclusion Criteria:

* currently use a sleep aid nightly
* diagnosed with insomnia or sleep apnea
* history of delirium with opiates or zolpidem
* allergic to opiates or zolpidem
* had previous lumbar spine surgery
* undergoing minimally invasive lumbar fusion,
* undergoing lumbar fusion for fracture, infection, tumor, or an inflammatory spondyloarthropathy

About the study

The purpose of this study is to evaluate if peri-operative zolpidem for posterior lumbar spinal fusion improves patient reported outcomes following surgery.

What is being tested

• Zolpidem Tartrate 10 mg (drug)
• Placebo (drug)

Sponsor: University of Southern California · Participants: 140 · Started: Feb 1, 2022

Contact the study team

• Pui Yan, MS · Phone: 323-442-6984

Official record on ClinicalTrials.gov — NCT05746143

Locations in the U.S.

Conditions

• Pain After Surgery

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.