Home › Respiratory Failure › NCT05751863

Analgesia-First Sedation in Trauma Patients

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

1. ≥ 18 years of age
2. Mechanically ventilated with an expected duration of MV ≥ 48h
3. Initiated continuous sedative/analgesic infusions by the ICU team
4. Patient is a candidate for MV weaning

Exclusion Criteria:

1. Admission after resuscitation from cardiac arrest
2. Significant neurological deficit due to a chronic disorder
3. History of alcohol dependence and/or other illicit drug abuse
4. Prior administration of continuous sedative/analgesic from a transferring institution
5. Patient receiving neuromuscular blocking agents
6. Allergy to midazolam, lorazepam, and/or propofol

About the study

The study's aim is to ascertain the best approach for providing sedation and pain management for patients who have sustained trauma and are requiring respiratory support from a mechanical ventilator. The common approach to patients who need mechanical ventilation is to provide continuous drips of sedatives and pain medicine and awaken the patient once a day to check the brain functions. Another approach is to provide pain medicine and reserve sedatives for only a short duration when needed. The difference between approaches has not been studied in Trauma patients.

What is being tested

• Analgesia First Sedation Strategy for Mechanically Ventilated (MV) Trauma Subjects (other)
• Protocol Directed Sedation and Daily Sedation Interruption (other)

Sponsor: MemorialCare Health System · Participants: 170 · Started: Apr 1, 2023

Contact the study team

• Maged Tanios, MD, MPH · Phone: 562-424-800
• Hyunsoon Park, RN · Phone: 562-933-7176

Official record on ClinicalTrials.gov — NCT05751863

Locations in the U.S.

Conditions

• Respiratory Failure

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.