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Blood Pressure Variability and Ischemic Stroke Outcome

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Ischemic stroke according to the American Heart Association (AHA) definition and either:

  1. CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or
  2. Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA)

     Onset of ischemic stroke within 48 hours and able to get baseline pMRI within 72 hours of arrival

     4\) NIH Stroke Scale ≥ 4 at time of enrollment

     Exclusion Criteria:
* Pre-morbid mRS ≥3
* Predicted hospital system admission \<72 hours
* Pacemaker or other MRI contraindications per American College of Radiology guidelines

About the study

The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are:

1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke. 2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome. 3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.

Sponsor: Yale University · Participants: 150 · Started: Jul 15, 2024

Contact the study team

• Adam de Havenon, MD · Phone: 203-785-4085

Official record on ClinicalTrials.gov — NCT05756257

Locations in the U.S.

Conditions

• Ischemic Stroke

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.