Home › Multiple Sclerosis › NCT05787795

Identifying and Characterizing Preclinical MS

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Age 18+
* Having one or more risk factors for multiple sclerosis, including one or more of the below:

  * Individuals known to have a radiologically isolated syndrome
  * Individuals with a family history of multiple sclerosis (first degree family member)
  * Individuals with personal risk factors, which are known to include smoking, obesity, Epstein Barr virus infections, Vitamin D deficiency, genetic risk score

Exclusion Criteria:

* Currently pregnant
* Diagnosis of multiple sclerosis or any ongoing, systemic autoimmune disease
* Ongoing treatment with immunosuppressive medications

About the study

The purpose of this research study is to try and identify risk factors and biologic changes that suggest that someone may go on to develop multiple sclerosis before a person has shown any symptoms of the disease.

What is being tested

• biological samples (other)

Sponsor: Yale University · Participants: 1,000 · Started: Jun 21, 2022

Contact the study team

• Erin Longbrake, MD · Phone: 860-287-6100

Official record on ClinicalTrials.gov — NCT05787795

Locations in the U.S.

Conditions

• Multiple Sclerosis

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.