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Brain Connectivity Changes With Spinal Cord Stimulation and Treatment of Chronic Pain: A Resting State NIRS/EEG Study

Brain Connectivity Changes With Spinal Cord Stimulation Treatment of Chronic Pain: A Resting State NIRS/EEG Study

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* 18 years of age and a US veteran
* Diagnosis of chronic neuropathic pain.
* Current patient at Cleveland VA Medical Center receiving care via Pain Medicine Center.
* Current user of tonic parasthesia-based SCS (pain relief 50% according to NPRS) or undergoing trial SCS period as part of clinical care.
* Able to provide informed consent.
* Medically and psychologically stable.

Exclusion Criteria:

* Metal in the skull or deformity of the skull
* Pregnancy or pregnancy planning during the study period.
* Unable to provide informed consent.

About the study

This study aims to assess how use of spinal cord stimulation for the treatment of chronic pain impacts brain structure and function. The investigators will use a non-invasive neuroimaging technique called resting state Near Infrared Spectroscopy and Electroencephalography (rs-fNIRS/EEG). The investigators will enroll Veterans who are currently receiving care at the Medical Center and who are either long term users of SCS for the treatment of their chronic pain or being evaluated for use of SCS to treat their pain.

Sponsor: VA Office of Research and Development · Participants: 40 · Started: Jul 1, 2023

Contact the study team

• Cheryl Dudek · Phone: (216) 679-3800
• Holly B Henry · Phone: (216) 791-3800

Official record on ClinicalTrials.gov — NCT05811312

Locations in the U.S.

Conditions

• Nerve Pain (Neuralgia)
• Chronic Pain

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.