Home › Opioid Overdose › NCT05829655

Measuring Acute Drug Demand in Humans

Who can join

Ages 18 to 65 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Age between 18 and 65 years old
* Meets Diagnostic and Statistical Manual-5 criteria for Opioid Use Disorder (OUD) (moderate or severe)
* Lifetime substance use history criterion \[blinded\]
* Medically cleared to take suvorexant and blinded study medications
* Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests

Exclusion Criteria:

* Pregnant or breast feeding
* Seeking opioid use treatment
* Significant mental health or physical disorder that is expected to interfere with study participation as assessed by the study physicians or medical staff
* Known contraindications or allergies to suvorexant and/or the blinded study medications

About the study

This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.

What is being tested

• Drug A (Blinded Drug) (drug)
• Drug B (Blinded Drug) (drug)
• Drug C (Blinded Drug) (drug)
• Drug D (Blinded Drug) (drug)
• Suvorexant (20mg/day) (drug)
• Placebo (drug)

Sponsor: University of Maryland, Baltimore · Participants: 75 · Started: Aug 8, 2023

Contact the study team

• Justin Strickland, PhD · Phone: 667-354-3516

Official record on ClinicalTrials.gov — NCT05829655

Locations in the U.S.

Conditions

• Opioid Overdose

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.