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Opioid Overdose clinical trials recruiting in the U.S.
178 studies for Opioid Overdose are recruiting participants at sites across the United States.
Opioid overdose leads to slowing or stopping of breathing and sometimes death. You can take steps to help prevent an overdose, and respond to one with naloxone.
Cities with the most studies
- New Haven, CT19 studies
- Baltimore, MD18 studies
- Philadelphia, PA14 studies
- New York City, NY13 studies
- Boston, MA11 studies
- Salt Lake City, UT8 studies
- Charleston, SC7 studies
- San Francisco, CA6 studies
- Birmingham, AL6 studies
- Pittsburgh, PA6 studies
- Chicago, IL5 studies
- Ann Arbor, MI5 studies
- Minneapolis, MN5 studies
- Providence, RI5 studies
- Indianapolis, IN5 studies
- Washington, DC5 studies
- Houston, TX4 studies
- Greenville, SC4 studies
- Morgantown, WV4 studies
- Columbus, OH4 studies
- Albuquerque, NM4 studies
- Seattle, WA4 studies
- The Bronx, NY4 studies
- Springfield, MA4 studies
- San Diego, CA4 studies
- Edison, NJ4 studies
- Tampa, FL3 studies
- Nashville, TN3 studies
- Meads, KY3 studies
- Bridgeport, CT3 studies
- Oakland, CA3 studies
- Lexington, KY3 studies
- Miami, FL3 studies
- Durham, NC3 studies
- Portland, OR3 studies
By state
- Alabama6 studies
- Arizona3 studies
- California20 studies
- Colorado3 studies
- Connecticut20 studies
- District of Columbia5 studies
- Florida7 studies
- Georgia3 studies
- Illinois6 studies
- Indiana6 studies
- Kentucky4 studies
- Maryland19 studies
- Massachusetts16 studies
- Michigan7 studies
- Minnesota8 studies
- New Jersey9 studies
- New Mexico5 studies
- New York17 studies
- North Carolina6 studies
- Ohio8 studies
- Oregon5 studies
- Pennsylvania23 studies
- Rhode Island6 studies
- South Carolina11 studies
- Tennessee3 studies
- Texas6 studies
- Utah8 studies
- Virginia3 studies
- Washington5 studies
- West Virginia6 studies
- Wisconsin4 studies
Recently updated studies
Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention
Recruiting
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT06843213VK4-116 Phase I Study With Food-Effect
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 60 · All sexes · Updated Nov 13, 2026 · NCT06808932A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk Aim 3
Recruiting
Ages 13 and older · All sexes · Updated Nov 10, 2026 · NCT07797933Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use
Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT06513156E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
RecruitingPhase 2
Ages 21 to 75 · All sexes · Updated Nov 9, 2026 · NCT05722561Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
Recruiting
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT06565416Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07369089A Study of Brenipatide in Participants With Opioid Use Disorder
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Nov 4, 2026 · NCT07420283Using Facebook to Support Opioid Recovery Among American Indian Women
Recruiting
Ages 18 and older · Women · Updated Nov 3, 2026 · NCT05995886Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage
RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Nov 3, 2026 · NCT07294118Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 21 to 60 · All sexes · Updated Oct 26, 2026 · NCT03745339A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Oct 23, 2026 · NCT07874620MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT06553196Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine
RecruitingEarly phase 1
Ages 18 to 70 · All sexes · Updated Oct 21, 2026 · NCT07886606Ketamine for Opioid Use Disorder
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Oct 20, 2026 · NCT06943859Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT07637994MethaLoad Dose-Finding Study
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT06877858The ENHANCE Project Toolkit
Recruiting
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07649278Cortical rTMS as a Treatment for Depression
Recruiting
Ages 18 to 64 · All sexes · Updated Oct 13, 2026 · NCT05487911Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder
Recruiting
Ages 18 to 60 · All sexes · Updated Oct 13, 2026 · NCT07318480Supporting Treatment Access and Recovery in COD
Recruiting
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT05138614Integrating MOUD in Nonmedical Community Settings (Better Together)
Recruiting
Ages 16 and older · All sexes · Updated Oct 13, 2026 · NCT06416020Semaglutide for Helping Opioid Recovery
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT06639464Supporting Treatment for Opioids and Recovery Capital (STORC) - R61 Phase
Recruiting
Ages 18 and older · Women · Updated Oct 9, 2026 · NCT07787039The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD)
RecruitingHealthy volunteers welcome
Ages 18 to 60 · All sexes · Updated Oct 9, 2026 · NCT06832007From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.