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Opioid Overdose clinical trials recruiting in the U.S.

179 studies for Opioid Overdose are recruiting participants at sites across the United States.

Opioid overdose leads to slowing or stopping of breathing and sometimes death. You can take steps to help prevent an overdose, and respond to one with naloxone.

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Recently updated studies

Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD

Recruiting
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06157840

Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder

RecruitingObservational study
Ages 18 to 50 · All sexes · Updated Sep 28, 2026 · NCT06487533

Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 3

Recruiting
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07793383

A Study of Brenipatide in Participants With Opioid Use Disorder

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07420283

Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder

RecruitingObservational studyHealthy volunteers welcome
Ages 12 to 89 · All sexes · Updated Sep 21, 2026 · NCT06526286

Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention

Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06843213

A Clinical Trial of Telehealth Treatment for Opioid Use Disorders

Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07362082

Study to Assess the Use of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid Use Disorder

RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 17, 2026 · NCT06538558

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

RecruitingHealthy volunteers welcome
Ages 18 and older · Women · Updated Sep 16, 2026 · NCT07179614

Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

RecruitingPhase 4
Ages 18 to 99 · All sexes · Updated Sep 14, 2026 · NCT06323824

Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial

Recruiting
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06565416

Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder

RecruitingObservational studyHealthy volunteers welcome
Ages 21 to 60 · All sexes · Updated Sep 11, 2026 · NCT03745339

OMAR Opioid Use Disorder

RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT05683184

A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT04375033

Using Facebook to Support Opioid Recovery Among American Indian Women

Recruiting
Ages 18 and older · Women · Updated Sep 4, 2026 · NCT05995886

Ketamine for Opioid Use Disorder

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Aug 31, 2026 · NCT06943859

Deep Brain Stimulation Effects In Patients With Opioid Use Disorder

Recruiting
Ages 22 to 65 · All sexes · Updated Aug 31, 2026 · NCT04354077

GLP-1R Agonist Treatment for Opioid Use Disorder

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 28, 2026 · NCT06548490

EMS-Initiated Buprenorphine

RecruitingObservational study
All ages · All sexes · Updated Aug 27, 2026 · NCT07475728

PRoducing Outcome Measures for OTP Quality Improvement

Recruiting
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07214389

Personalized Addiction Treatment enHancement

Recruiting
Ages 22 and older · All sexes · Updated Aug 26, 2026 · NCT07778394

Ketones for Opioid Craving

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 25, 2026 · NCT07128524

Shelter HArm Reduction Evaluation

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT07170072

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.