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Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Who can join

Ages 65 and older · All sexes

Inclusion Criteria:

* Age 65+
* Objective executive function decline, based on standardized cognitive assessments.
* Subjective cognitive decline, based on the question: "During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?"
* Ability to walking independently for 6 minutes (use of cane permitted)

Exclusion Criteria:

* Major cognitive disorder that interferes with independence
* Percentile score less than 10th percentile on standardized cognitive assessments
* Medications that are thought to influence tDCS neuroplasticity.
* Contraindications to tDCS or MRI.

About the study

Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.

What is being tested

• Walking Exercise (behavioral)
• Prefrontal Active tDCS (device)
• Prefrontal Sham tDCS (device)

Sponsor: University of Florida · Participants: 120 · Started: Apr 15, 2024

Contact the study team

• David J Clark, ScD · Phone: 352-376-1611

Official record on ClinicalTrials.gov — NCT05830942

Locations in the U.S.

Conditions

• Mild Cognitive Impairment

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.