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Automated Robotic TCD in Traumatic Brain Injury

RecruitingObservational study

Automated Robotic TCD in Traumatic Brain Injury (ART-TBI)

Who can join

Ages 18 and older · All sexes

Full eligibility criteria

Inclusion Criteria:

* Adults ≥18
* Blunt TBI with Glasgow Coma Score (GCS) ≤8
* Injury within 72 hours
* Adequate TCD windows
* Ability to obtain informed consent from a Legally Authorized Representative (LAR)

Exclusion Criteria:

* Catastrophic brain injury with grim prognosis (e.g.: GCS 3 with bilateral mid-position pupil)
* C- spine fracture with evidence of spinal cord injury
* Severe skull or scalp injury precluding device placement
* Planned decompressive hemicraniectomy
* Continuous fever for \>6 hours at the time of enrollment (despite treatment)
* Lack of TCD window

About the study

This study's objective is to determine the safety, feasibility and efficacy of prolonged automated robotic TCD monitoring in critically ill patients with severe TBI across multiple clinical sites with varying levels of TCD availability and experience

What is being tested

Transcranial Doppler ultrasonography (TCD) (device)

Sponsor: Virginia Commonwealth University · Participants: 30 · Started: May 20, 2025

Contact the study team

Shraddha Mainali, MD · Phone: (804) 828-5269
Matthew Ridder · Phone: (804) 828-5269

Official record on ClinicalTrials.gov — NCT05848297

Locations in the U.S.

California	University of California, Davis, Davis (Not yet recruiting)
North Carolina	Wake Forest University, Winston-Salem (Not yet recruiting)
Virginia	Virginia Commonwealth University, Richmond

Conditions

Traumatic Brain Injury

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.