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buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest (RESTORE)

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

1. Age ≥18 years old
2. Non-traumatic, out-of-hospital cardiac arrest
3. Comatose on admission - defined as not following commands
4. Return of spontaneous circulation (ROSC) within less than 45 minutes
5. Admission to the intensive care unit
6. Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous

EEG monitoring within 7 days from ROSC

Exclusion Criteria:

1. Acute cerebral hemorrhage or infarction
2. Pregnancy
3. Prisoners

About the study

RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.

What is being tested

• Burst Suppression EEG Target Intravenous Anesthesia (drug)
• Seizure Suppression EEG Target Intravenous Anesthesia (drug)

Sponsor: University of California, San Francisco · Participants: 30 · Started: Aug 7, 2023

Contact the study team

• Edilberto Amorim, MD · Phone: 628-206-3203
• Kevin Bao · Phone: (415)514-2120

Official record on ClinicalTrials.gov — NCT05851391

Locations in the U.S.

Conditions

• Brain Hypoxia-Ischemia
• Sudden Cardiac Arrest
• Status Epilepticus
• Seizures

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.