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Ovarian Tissue Cryopreservation for Fertility Preservation
Ovarian Tissue Cryopreservation for Fertility Preservation in Patients Facing Infertility-causing Diseases or Treatment Regimens
Who can join
Up to age 39 · Women
Full eligibility criteria
Inclusion Criteria: * Be female age less than 40 years old. * Unable or unwilling to make use of oocyte or embryo banking alone. * Be scheduled to undergo surgery, chemotherapy, drug treatment and/or radiation for the treatment or prevention of a medical condition or malignancy with risk of causing permanent and complete loss of subsequent ovarian function. * Or, have a medical condition or malignancy that requires removal of all or part of one or both ovaries. * Or, Have newly diagnosed or recurrent disease. Those who were not enrolled at the time of initial diagnosis (i.e., patients with recurrent disease) are eligible if they have not previously received therapy that is viewed as likely to result in complete and permanent loss of ovarian function. * Have two ovaries if undergoing elective removal of an ovary for fertility preservation only. Exclusion Criteria: * Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent. * Diagnosed with an underlying medical condition that significantly increases their risk of complications from anesthesia and surgery.
About the study
The goal of this observational study is to learn about fertility preservation for pre-pubertal, peri-pubertal, and adult participants that are unable to pursue clinical standard of care fertility preservation such as egg (oocyte) and embryo cryopreservation.
In addition, this study will provide research tissue for the following Specific Aims:
1. To optimize techniques for cryopreservation of ovarian tissues from patients at significant risk for infertility. 2. To investigate factors affecting successful maturation ovarian tissue.
Participants will undergo a surgical procedure to remove an ovary (oophorectomy) to preserve their gonadal tissue for fertility preservation.
What is being tested
- Infectious Disease Labwork (diagnostic test)
- Fertility-Based Labwork (diagnostic test)
Sponsor: University of Pittsburgh · Participants: 500 · Started: Jan 13, 2011
Contact the study team
- Rachel Neelley, BA · Phone: 4126417475
Official record on ClinicalTrials.gov — NCT05875155
Locations in the U.S.
| Pennsylvania | Magee-Womens Hospital, Pittsburgh |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.