Home › Post-COVID Conditions (Long COVID) › NCT05880108

Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

Who can join

Up to age 80 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

1. U.S. Veteran
2. Self-reported COVID-19 naïve or COVID-19 \> 90 days ago for lean and obese PCC naïve or documented COVID-19 for the lean and obese PCC groups (At least one PCC symptom \>4 weeks)
3. Body Mass Index: 19-25 or 30-50 kg/m2

Exclusion Criteria:

1. Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments
2. Active inflammatory, COVID-19, autoimmune, infectious, hepatic (LFTs \> 2.5 x WNL), renal (eGFR\<45), gastrointestinal, malignant, and psychiatric disease
3. Uncontrolled diabetes (HbA1c \>10% or the current use of insulin)
4. Weight change within the past month of \>5 kg
5. Self-reported alcohol or drug abuse
6. Anti-coagulant medication usage

About the study

The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.

What is being tested

• 12-weeks of Weight Loss (behavioral)
• 12-weeks of Weight Stability (behavioral)

Sponsor: VA Office of Research and Development · Participants: 150 · Started: Jun 3, 2024

Contact the study team

• Kristina Marcus, MS · Phone: (410) 605-7000

Official record on ClinicalTrials.gov — NCT05880108

Locations in the U.S.

Conditions

• Post-COVID Conditions (Long COVID)
• Obesity
• Weight Control

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.