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Immune Function and the Progression to T1D
Immune Function and the Progression to Type 1 Diabetes:
Who can join
Ages 0 to 100 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: able to have blood drawn - Exclusion Criteria: none \-
About the study
To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.
What is being tested
- blood draw (other)
Sponsor: University of Florida · Participants: 2,800 · Started: Jan 1, 2005
Contact the study team
- Jennifer L Hosford, MPH · Phone: 352-294-5759
- Kieran McGrail · Phone: (352) 273-9299
Official record on ClinicalTrials.gov — NCT05899439
Locations in the U.S.
| Florida | Kieran McGrail, Gainesville |
| Ohio | The Ohio State University, Columbus |
| Texas | Baylor College of Medicine, Center for Research Advancement - Texas Children's Hospital, Houston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.