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Combined Respiratory Training in Persons With ALS

Combined Respiratory Training to Improve Pulmonary and Cough Function in Persons With ALS

Who can join

Ages 18 to 90 · All sexes

Inclusion Criteria:

1. A diagnosis of probable or definite ALS in accordance with the Revisited El-Escorial Criteria.
2. Disease duration from symptom onset of ≤ 2 years,
3. Lung volume recruitment and expiratory muscle strength training naïve,
4. Reduced peak cough flow (% predicted for age and gender).

Exclusion Criteria:

1. History of stroke, head and neck cancer or other concomitant disorder that might contribute to dysphagia or respiratory impairment.
2. Use of prescription cough assist or non-invasive volume ventilation devices.
3. Enrollment in another research investigation that might impact cough or respiratory function.
4. Diagnosis of frontotemporal dementia or advanced cognitive impairment.
5. Tracheostomy placement/Use of invasive mechanical ventilation.
6. Contraindications for respiratory training (i.e., history of pneumothorax, severe chronic obstructive pulmonary disease).

About the study

The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed:

1. Determine the impact of combined LVR and EMST on cough strength and respiratory function in individuals with ALS. 2. Determine the impact of combined LVR and EMST on patient-reported dyspnea and bulbar impairment. 3. Describe the effect of combined LVR and EMST on patient- and caregiver reported burden and quality of life.

What is being tested

• Respiratory Muscle Strength Training (LVR+EMST) (device)

Sponsor: Nova Southeastern University · Participants: 34 · Started: Aug 22, 2023

Contact the study team

• Lauren Tabor Gray, PhD · Phone: 954-262-8963
• Donovan Mott · Phone: 954-203-2829

Official record on ClinicalTrials.gov — NCT05913882

Locations in the U.S.

Conditions

• Respiratory Failure
• Swallowing Disorders

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.