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Impulsivity Domains and Subjective Response

RecruitingEarly phase 1Healthy volunteers welcome

Linking Impulsivity Domains and Subjective Response to Alcohol in Young Adults Using Lab and Daily Assessment Methods

Who can join

Ages 21 to 25 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* 21-25 years old
* Report drinking to an estimated BAC \> .08% at least once in the past 30 days based on responses on the Timeline Followback (TLFB)
* Report drinking at least twice weekly in the past 30 days based on responses on the TLFB
* Fluency in English

Exclusion Criteria:

* Any serious medical problems (e.g., liver disease, cardiac abnormality, pancreatitis, diabetes, neurological problems, and gastrointestinal disorders)
* Body weight \< 110 or \> 210 pounds
* Axis I psychiatric disorders including substance use disorder other than mild or moderate alcohol or mild cannabis use disorder
* Current alcohol withdrawal or history of medically-assisted detoxification
* Two positive breath alcohol concentration (BrAC) readings (i.e., \> 0.00%) at an in-person screening appointment or experimental session
* Positive urine screen for illegal drugs other than cannabis
* Currently seeking or past-12-month history of inpatient or intensive treatment for addictive behaviors
* Current psychotropic medication use or receipt of a prescription for these medications in the past 30 days
* Psychosis or other psychiatric disability
* Pregnancy, nursing or lack of reliable birth control use for women
* Report smoking \> 5 cigarettes per day (to avoid acute nicotine effects or withdrawal during experimental sessions)

About the study

Findings from this project will determine the relationship between two vulnerability factors for Alcohol Use Disorder (AUD) in young adults: impulsivity and subjective response to alcohol. The results will identify badly needed, novel targets for prevention and treatment efforts to simultaneously reduce impulsivity and subjective responses in at-risk young adults.

What is being tested

Sponsor: Jessica Weafer · Participants: 250 · Started: Apr 1, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT05929677

Locations in the U.S.

MassachusettsNortheastern University, Boston
OhioOhio State University, Columbus

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.