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Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0 (TRAIN-AD 2.0)

Who can join

Ages 60 to 106 · All sexes

Inclusion Criteria:

1. Age \> 60
2. A diagnosis of dementia (any type)
3. Cognitive Functional Scale (CFS) \> 1
4. NH length of stay \>90 days

The CFS score categorizes cognitive impairment status based on data in the electronic health record into: 1. None, 2. Mild, 3. Moderate, and 4. Severe (advanced). For the primary outcome, the analysis will be restricted to residents with a CFS score of 3 or 4.

Exclusion Criteria:

1. Less than 60 years of age
2. Living in nursing home for less than 90 days
3. Does not have diagnosis of dementia
4. Does not meet CFS \>1 score

About the study

The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing homes randomized to use a multicomponent intervention to optimize suspected infection management ( versus usual care) use less antibiotics and fewer burdensome interventions.

What is being tested

• TRAIN AD 2.0 (behavioral)

Sponsor: Hebrew SeniorLife · Participants: 750 · Started: Nov 13, 2023

Contact the study team

• Susan Mitchell, MD, MPH · Phone: 16172813669

Official record on ClinicalTrials.gov — NCT05950607

Locations in the U.S.

Conditions

• Dementia
• Alzheimer's Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.