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Identifying and Treating Depression in the Orthopaedic Trauma Population

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patients presenting to an Orthopaedic trauma clinic for the first time following operative extremity fracture or any pelvis fracture
* A score of greater than or equal to 5 on the Patient Health Questionnaire-9 (PHQ-9) at first post- operative visit
* Age 18 or older
* Speak English or Spanish

Exclusion Criteria:

* Currently taking medication to treat depression
* Contraindication/allergy to one of the study medications
* Bipolar disorder of psychotic disorder
* Endorse suicidal ideation

About the study

The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are:

1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed either an Selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI). 2. What are the outcomes of patients who screen positive for depressive symptoms and choose not to pursue treatment with medication?

What is being tested

• Fluoxetine 20 MG (drug)
• Duloxetine 30 MG (drug)
• Observation (other)

Sponsor: Wake Forest University Health Sciences · Participants: 100 · Started: Jun 25, 2025

Contact the study team

• Erica Grochowski, MPH · Phone: 704-403-4980

Official record on ClinicalTrials.gov — NCT05976347

Locations in the U.S.

Conditions

• Depression

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.