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A Registry for People With T-cell Lymphoma

RecruitingObservational study

The T-cell Lymphoma Master Repository (TCLMR): A Prospective Databank of Patients With T-cell Lymphoma With Clinical Annotation and Matched Tumor Specimens

Who can join

All ages · All sexes

Full eligibility criteria
Inclusion Criteria:

* Written informed consent
* Adequate fresh or archival tumor biopsy or intent to obtain fresh tumor biopsy.
* Pathologically-confirmed mature T- or natural killer (NK)-cell lymphoma meeting one of the following diagnostic criterion (based on WHO classification and NCCN guidelines):

  * T-cell prolymphocytic leukemia
  * T-cell large granular lymphocytic leukemia
  * Chronic lymphoproliferative disorder of NK cells
  * Aggressive NK-cell leukemia
  * Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoma of childhood
  * Chronic active EBV infection of T- and NK-cell type, systemic form
  * Hydroa vacciniforme-like lymphoproliferative disorder
  * Adult T-cell leukemia/lymphoma
  * Extranodal NK/T-cell lymphoma, nasal type
  * Enteropathy-associated T-cell lymphoma
  * Monomorphic epitheliotropic intestinal T-cell lymphoma
  * Intestinal T-cell lymphoma, not otherwise specified (NOS)
  * Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract
  * Hepatosplenic T-cell lymphoma
  * Subcutaneous panniculitis-like T-cell lymphoma
  * Mycosis fungoides (limited to those with ≥ stage IB disease and those receiving active therapy)
  * Sézary syndrome
  * Primary cutaneous anaplastic large cell lymphoma (receiving systemic therapy)
  * Primary cutaneous Gamma-Delta T-cell lymphoma
  * Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
  * Primary cutaneous acral CD8+ T-cell lymphoma (receiving systemic therapy)
  * Peripheral T-cell lymphoma, not otherwise specified
  * Angioimmunoblastic T-cell lymphoma
  * Follicular T-cell lymphoma
  * Nodal peripheral T-cell lymphoma with TFH phenotype
  * Anaplastic large cell lymphoma, ALK-positive
  * Anaplastic large cell lymphoma, ALK-negative
  * Breast-implant associated anaplastic large cell lymphoma.
* NOTE: Patients with diagnoses of mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, and/or primary cutaneous acral CD8+ T-cell lymphoma must be receiving systemic therapy.

Exclusion Criteria:

* Patients with of mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, and/or primary cutaneous acral CD8+ T-cell lymphoma not receiving systemic therapy.
* Inability to collect prospective data, measure response, or perform adequate follow-up assessments in the clinical judgment of the treating physician. NOTE: Repository participation does not exclude participation in clinical trials, nor does existing clinical trial participation exclude enrollment in the study herein outlined.

About the study

The purpose of this registry study is to create a database-a collection of information-for better understanding T-cell lymphoma. Researchers will use the information from this database to learn more about how to improve outcomes for people with T-cell lymphoma.

What is being tested

Sponsor: Memorial Sloan Kettering Cancer Center · Participants: 1,000 · Started: Jul 27, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT05978141

Locations in the U.S.

CaliforniaCity of Hope Cancer Center (Data collection only), Duarte (Not yet recruiting)
UNIVERSITY OF CALIFORNIA SAN DIEGO (Data collection only), San Diego (Not yet recruiting)
University of California San Francisco (Data collection only), San Francisco (Not yet recruiting)
Stanford University Medical Center (Data collection only), Stanford (Not yet recruiting)
ColoradoUniversity of Colorado (Data Collection Only), Aurora (Not yet recruiting)
ConnecticutYale University (Data Collection Only), New Haven (Not yet recruiting)
FloridaUniversity of Miami (Data Collection Only), Miami (Not yet recruiting)
Moffitt Cancer Center (Data Collection Only), Tampa (Not yet recruiting)
GeorgiaEmory University (Data Collection Only), Atlanta (Not yet recruiting)
IllinoisNorthwestern Medicine (Data Collection), Chicago (Not yet recruiting)
MassachusettsDana Farber Cancer Institute (Data Collection Only), Boston (Not yet recruiting)
Massachusetts General Hospital (Data Collection Only), Boston (Not yet recruiting)
MinnesotaMayo Clinic (Data Collection Only), Rochester (Not yet recruiting)
MissouriWashington University (Data Collection Only), St Louis (Not yet recruiting)
NebraskaUniversity of Nebraska (Data collection only), Omaha (Not yet recruiting)
New JerseyMemorial Sloan Kettering at Basking Ridge (All protocol activities), Basking Ridge
Memorial Sloan Kettering Monmouth (All protocol activities), Middletown
New YorkMemorial Sloan Kettering Cancer Center @ Suffolk-Commack (All protocol activities), Commack
Memorial Sloan Kettering Westchester (All protocol activities), Harrison
Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York
Weill Cornell Medical Center (Data Collection Only), New York (Not yet recruiting)
Memorial Sloan Kettering Nassau (All protocol activities), Uniondale
OhioOhio State University (Data Collection Only), Columbus (Not yet recruiting)
PennsylvaniaThomas Jefferson University Hospital (Data collection only), Philadelphia (Not yet recruiting)
University of Pennsylvania (Data Collection Only), Philadelphia (Not yet recruiting)
TexasMD Anderson Cancer Center (Data Collection Only), Houston (Not yet recruiting)

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.