Home › Dementia › NCT06042413

Prediction and Prevention of Postoperative Mortality and Morbidity

Real-world and Innovative Multimodal Prediction and Prevention of Postoperative Mortality and Multi-morbidities

Who can join

Ages 65 and older · All sexes

Part I Inclusion Criteria:

* 65 years of age and older
* Scheduled for major cardiac surgeries including coronary artery bypass and valvular repair and/or vascular surgeries including carotid endarterectomy, aortic aneurysm repair, and major vascular surgeries
* Informed consent
* English speaking patients

Part II Inclusion Criteria:

* Enrolled in Aim 1 / Part I Preoperative Intervention Trial
* Scheduled for high-risk, cardiac or vascular surgery requiring intraoperative neurophysiological monitoring (IONM)

Part I Exclusion Criteria:

* Children (\<18 years)
* Patients unable to provide consent
* Participants undergoing same day procedures or operations (discharged same day)
* Patients with severe preoperative medical diseases such as blindness or significant visual impairment, unresolved motor weakness, or any other perioperative events or complications that would have a bearing on the patient's ability to perform study tasks, neuropsychological tests, and proposed interventions

Part II Exclusion Criteria:

* Pregnant women
* Patients do not provide consent.
* Patients are unable to participate in cognitive and other behavioral assessment due to physical limitations
* Patients refuse any blood transfusions during surgery

About the study

This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive outcomes following elective cardiac and vascular surgery in older adults. It will evaluate associations between perioperative factors and longer-term neurocognitive outcomes, including postoperative neurocognitive disorder and dementia. In addition, this study will assess scalable, multimodal preoperative and intraoperative interventions to improve perioperative outcomes.

This study will explore two main hypotheses:

1. Preoperative personalized prehabilitation with proactive cognitive and behavioral interventions will improve postoperative cognitive outcomes, morbidity, and mortality in high-risk elderly surgical patients. 2. Proactive bundled intraoperative interventions are superior to reactive standard of care in reducing postoperative cognitive outcomes, MACCE, and mortality.

Expected Outcome: Improved EHR algorithm will have higher predictive accuracy for MACCE and mortality while predicting postoperative cognitive outcomes.

What is being tested

• Personalized CPC Prehabilitation (other)
• Cognitive Training (behavioral)
• Meditation (behavioral)
• Daily Exercise (behavioral)
• Enhanced Social Support (behavioral)
• Proactive Bundle Interventions (other)

Sponsor: University of Pittsburgh · Participants: 1,200 · Started: Oct 23, 2026

Contact the study team

• Alisha Maslanka, BS, CCRC · Phone: 4128646779
• Dayana Alsamsam, BSPS, MSc · Phone: 412-623-4147

Official record on ClinicalTrials.gov — NCT06042413

Locations in the U.S.

Conditions

• Dementia
• Emergence Delirium
• Mild Cognitive Impairment

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.