Home › Leg Injuries and Disorders › NCT06050668
Essential Amino Acid Supplementation for Femoral Fragility Fractures
MEND Repair & Recover Clinical Trial
Who can join
Ages 65 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Hospital inpatient * Age ≥ 65 years old on admission * Low-energy mechanism of injury * Diagnosis of femur fracture (OTA 31, 32, or 33 fracture) * Indicated for surgical fixation * Able to provide informed consent Exclusion Criteria: * Part of a vulnerable population (ex: Incarcerated, Non-English speaking) * Cognitive impairment (MMSE score ≤ 17) * Electrical medical implant (ex: Pacemaker/Defibrillator, Left Ventricular Assist Device, Cochlear implant, Insulin pump, Pain medication pumps, Spinal cord stimulator) * Non-ambulatory prior to injury * Inability to consume an oral diet or allergy to supplement ingredients (ex: milk allergy) * Concern for inability to complete follow-up * Hemi or total arthroplasty (joint replacement) * Patients with a historical diagnosis of chronic kidney disease (CKD)
About the study
This trial will evaluate the impact of 4 weeks of postoperative essential amino acid (EAA)-based supplementation on muscle morphology after femoral fragility fracture. This trial will assess the ability of EAA-based to increase skeletal muscle metabolic activity, reduce inflammation, and induce muscle fiber hypertrophy, as well as preserve skeletal muscle mass and physical performance up to 6 months after injury. Participants will be randomized in a 1:1 ratio to 1) standard of care (no dietary intervention) or 2) EAA-based supplementation.
What is being tested
- Essential Amino Acid Supplementation (combination product)
Sponsor: Michael C Willey · Participants: 60 · Started: Jun 17, 2024
Contact the study team
- Michael C Willey, MD · Phone: 319-384-8452
- Ashley S Kochuyt, BS · Phone: 319-929-3559
Official record on ClinicalTrials.gov — NCT06050668
Locations in the U.S.
| Iowa | University of Iowa Health Care, Iowa City |
| Oregon | Slocum Center for Orthopedics & Sports Medicine, Eugene (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.