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Leg Injuries and Disorders clinical trials recruiting in the U.S.

34 studies for Leg Injuries and Disorders are recruiting participants at sites across the United States.

Leg injuries and leg disorders can affect the whole leg or just one part. Read about common leg injuries such as sprains, strains, and fractures.

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Recently updated studies

Accelerated Flap Coverage in Severe Lower Extremity Trauma

Recruiting
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT06293469

Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care

RecruitingObservational study
All ages · All sexes · Updated Sep 15, 2026 · NCT04299022

PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05699174

MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

Recruiting
Ages 60 and older · All sexes · Updated Sep 9, 2026 · NCT07244211

MY01 Pressure Monitoring in Adolescent Tibia Fractures

Recruiting
Ages 10 to 21 · All sexes · Updated Aug 27, 2026 · NCT07674043

Blood Flow Restriction Training After Patellar INStability

Recruiting
Ages 14 to 40 · All sexes · Updated Aug 21, 2026 · NCT04554212

Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT05421741

IM ABLE 2: Injuries Managed With Advanced Bracing for Lower Extremities

Recruiting
Ages 18 to 80 · All sexes · Updated Jul 23, 2026 · NCT07721792

Tibial IMN Vs. Tibial Micromotion IMN

Recruiting
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT06976801

Intramedullary Calcium Sulfate Antibiotic Depot

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05766670

Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures

RecruitingPhase 3
Ages 18 and older · All sexes · Updated May 12, 2026 · NCT06337292

Essential Amino Acid Supplementation for Femoral Fragility Fractures

RecruitingPhase 2
Ages 65 and older · All sexes · Updated Apr 15, 2026 · NCT06050668

Retrograde Femoral Nail-Advanced Outcomes for Fixation of Distal Femur and Femoral Shaft Fractures

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Feb 9, 2026 · NCT05680987

A Case Series: TRUMATCH Graft Cage for Segmental Long Bone Defects

RecruitingObservational study
Ages 18 and older · All sexes · Updated Feb 9, 2026 · NCT05668182

Miro3D Wound Matrix Study for Diabetic Foot Ulcers and Wound Healing

Recruiting
Ages 18 and older · All sexes · Updated Dec 24, 2025 · NCT06939686

Total Contact Soft Cast in Diabetic Foot Ulcers

Recruiting
Ages 18 and older · All sexes · Updated Dec 15, 2025 · NCT04210089

Blood Flow Restriction Training in Patients With Lower Extremity Fractures

RecruitingHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Nov 21, 2025 · NCT06496035

Blood Flow Restriction Therapy in Lower Limb Extensor Injuries

RecruitingHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 26, 2025 · NCT04149977

Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool

Recruiting
Ages 18 and older · All sexes · Updated Sep 26, 2025 · NCT07193524

Correlating Multispectral Near-Infrared Imaging to Standard Vascular Diagnostics

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 11, 2025 · NCT06899113

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.