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Leg Injuries and Disorders clinical trials recruiting in the U.S.
33 studies for Leg Injuries and Disorders are recruiting participants at sites across the United States.
Leg injuries and leg disorders can affect the whole leg or just one part. Read about common leg injuries such as sprains, strains, and fractures.
Cities with the most studies
- Nashville, TN7 studies
- Charlotte, NC5 studies
- Baltimore, MD5 studies
- New York City, NY4 studies
- Los Angeles, CA3 studies
- Lexington, KY3 studies
- Roanoke, VA3 studies
- Harrisburg, PA3 studies
- Chicago, IL3 studies
- Winston-Salem, NC3 studies
- Boston, MA3 studies
- Minneapolis, MN3 studies
- Houston, TX3 studies
By state
- California7 studies
- Florida6 studies
- Illinois3 studies
- Kentucky3 studies
- Maryland5 studies
- Massachusetts4 studies
- Minnesota3 studies
- New York6 studies
- North Carolina6 studies
- Ohio3 studies
- Pennsylvania7 studies
- Tennessee7 studies
- Texas5 studies
- Virginia5 studies
Recently updated studies
Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS)
Recruiting
Ages 18 to 60 · All sexes · Updated Nov 12, 2026 · NCT05889559MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)
Recruiting
Ages 60 and older · All sexes · Updated Nov 10, 2026 · NCT07244211MY01 Pressure Monitoring in Adolescent Tibia Fractures
Recruiting
Ages 10 to 21 · All sexes · Updated Oct 23, 2026 · NCT07674043Intramedullary Calcium Sulfate Antibiotic Depot
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 14, 2026 · NCT05766670Essential Amino Acid Supplementation for Femoral Fragility Fractures
RecruitingPhase 2
Ages 65 and older · All sexes · Updated Oct 7, 2026 · NCT06050668Total Contact Soft Cast in Diabetic Foot Ulcers
Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT04210089Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
Recruiting
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07364630Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.
RecruitingPhase 4
Ages 21 and older · All sexes · Updated Sep 22, 2026 · NCT06826339Accelerated Flap Coverage in Severe Lower Extremity Trauma
Recruiting
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT06293469Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care
RecruitingObservational study
All ages · All sexes · Updated Sep 15, 2026 · NCT04299022PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05699174Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.
Recruiting
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06437028Blood Flow Restriction Training After Patellar INStability
Recruiting
Ages 14 to 40 · All sexes · Updated Aug 21, 2026 · NCT04554212Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT05421741IM ABLE 2: Injuries Managed With Advanced Bracing for Lower Extremities
Recruiting
Ages 18 to 80 · All sexes · Updated Jul 23, 2026 · NCT07721792Comparison of Healing Measures Tibial Fractures Following Standard Intramedullary Nailing or Micromotion Tibial Intramedullary Nailing
Recruiting
Ages 18 to 85 · All sexes · Updated Jul 14, 2026 · NCT06679049Tibial IMN Vs. Tibial Micromotion IMN
Recruiting
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT06976801Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures
RecruitingPhase 3
Ages 18 and older · All sexes · Updated May 12, 2026 · NCT06337292A Case Series: TRUMATCH Graft Cage for Segmental Long Bone Defects
RecruitingObservational study
Ages 18 and older · All sexes · Updated Feb 9, 2026 · NCT05668182Retrograde Femoral Nail-Advanced Outcomes for Fixation of Distal Femur and Femoral Shaft Fractures
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Feb 9, 2026 · NCT05680987Miro3D Wound Matrix Study for Diabetic Foot Ulcers and Wound Healing
Recruiting
Ages 18 and older · All sexes · Updated Dec 24, 2025 · NCT06939686Blood Flow Restriction Training in Patients With Lower Extremity Fractures
RecruitingHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Nov 21, 2025 · NCT06496035Blood Flow Restriction Therapy in Lower Limb Extensor Injuries
RecruitingHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 26, 2025 · NCT04149977Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool
Recruiting
Ages 18 and older · All sexes · Updated Sep 26, 2025 · NCT07193524Correlating Multispectral Near-Infrared Imaging to Standard Vascular Diagnostics
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 11, 2025 · NCT06899113From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.