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Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans
Who can join
Ages 21 to 60 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: -Ages 21-60 years old Exclusion Criteria: * Major or unstable medical conditions based on history, the Structured Clinical Interview for DSM-5, collateral information, physical and laboratory examinations, ECG, and vital signs. * Cannabis naïve individuals * Positive pregnancy test
About the study
Cannabis is widely used worldwide and is associated with negative outcomes including cannabis use disorder (CanUD), psychosis, and cognitive impairment amongst others. Given the legalization of "recreational" and "medical" cannabis globally, the increasing availability of cannabis, the higher potency of cannabis, the availability of highly potent cannabinoid products, the commercialization of cannabis, and the rising rates of cannabis use, it is critical to understand how genetic factors influence 1) an individual's vulnerability for addiction and psychosis, 2) the response to cannabinoids, 3) the response to novel treatments for CanUD. CanUD is strongly genetically influenced; the investigators published the first CanUD genomewide association study (GWAS) with genomewide-significant results; however, the precise nature of the contribution of genetic factors in the development of CanUD is still not clear. Cannabis exposure has also been linked to a number of psychosis outcomes including schizophrenia (SCZ). SCZ is highly heritable and population-based and genetics studies both support a bidirectional genetic relationship between SCZ and CanUD. However, the precise contribution of genetic factors in the development of psychosis outcomes related to cannabis are not clear.
What is being tested
- Delta-9-THC Very Low Dose (drug)
- Placebo (drug)
- Delta-9-THC Medium Dose (drug)
Sponsor: Yale University · Participants: 215 · Started: Sep 16, 2024
Contact the study team
- Erik Zorrilla, PhD · Phone: 203-932-5711
- Deepak D'Spouza, MD · Phone: 203-932-5711
Official record on ClinicalTrials.gov — NCT06058702
Locations in the U.S.
| Connecticut | West Haven Veterans Affairs Medical Center, West Haven |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.