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Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

RecruitingObservational studyHealthy volunteers welcome

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

1. Are willing to voluntarily participate and sign the study consent
2. Know/suspect they have SCT and are willing to get tested to confirm/learn about their SCT status
3. Adults ages 18 and older

Exclusion Criteria:

1. Unwilling to sign consent
2. Known end-stage renal disease or dialysis
3. Known SCD (including sickle cell-beta thalassemia)
4. People who do not have SCT

About the study

The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.

What is being tested

Sponsor: National Alliance for Sickle Cell Centers · Participants: 1,000 · Started: Apr 1, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT06071377

Locations in the U.S.

AlabamaUniversity of Alabama, Birmingham
CaliforniaLoma Linda University Health Care, Loma Linda
DelawareNemours Children's Hospital, Wilmington
IndianaIndiana University, Indianapolis
MichiganFunctional Fluidics, Detroit
North CarolinaUniversity of North Carolina, Chapel Hill
Duke University, Durham
East Carolina University, Greenville
OhioNationwide Children's Hospital, Columbus
TexasUT Health Houston, Houston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.