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Sickle Cell Trait clinical trials recruiting in the U.S.
7 studies for Sickle Cell Trait are recruiting participants at sites across the United States.
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Recently updated studies
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
RecruitingPhase 3
Ages 12 to 100 · All sexes · Updated Nov 10, 2026 · NCT06439082Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Nov 5, 2026 · NCT05904093Blood Sampling for Research Related to Sickle Cell Disease
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 26, 2026 · NCT00542230Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT06071377131I-apamistamab-based Conditioning for Hematopoietic Stem Cell Transplant (HSCT) in Advanced Sickle Cell Disease (SCD)
RecruitingPhase 1
Ages 12 to 50 · All sexes · Updated Jun 10, 2026 · NCT07015684Sickle Cell Kidney Biorepository
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Apr 13, 2026 · NCT07064174Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait
RecruitingObservational studyHealthy volunteers welcome
Ages 50 and older · Women · Updated Jul 24, 2025 · NCT07083531From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.