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Effect of Anti-inflammatory Diet in Osteoarthritis
An Evaluator-blinded Randomized Controlled Trial Study of the Effect of Anti-inflammatory Diet in Subjects With Osteoarthritis
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Unilateral radiographic symptomatic KOA * No changes in therapy during the previous 3 months * Interested in dietary intervention and able to provide consent and attend follow-up visits Exclusion Criteria: * Previous knee surgery * Severe radiographic disease (KL grade 4) * Rheumatoid Arthritis * Any Abnormal blood values in the comprehensive metabolic panel test at screen (Abnormality will be defined based on standard reference ranges) * Use of corticosteroids and/or intra-articular injections during the preceding 3 months * Use of fish oils and glucosamine * Participation in a weight loss program in the preceding 6 months * Recent changes in physical activity levels * Regular smoking * Patients with food allergies * Patient with other medical conditions that will impair the ability to participate in a nutritional study * Plan to change systemic therapy * Patients unwilling to change dietary habits
About the study
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites.
What is being tested
- Anti-inflammatory Diet (other)
- Healthy Diet (other)
Sponsor: University of California, San Diego · Participants: 72 · Started: Oct 1, 2023
Contact the study team
- Monica Guma, M.D., PhD · Phone: 8588226523
Official record on ClinicalTrials.gov — NCT06080347
Locations in the U.S.
| California | University of California, San Diego |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.