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Knee Osteoarthritis clinical trials recruiting in the U.S.

80 studies for Knee Osteoarthritis are recruiting participants at sites across the United States.

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Recently updated studies

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT05986292

ARVIS TKA vs Conventional TKA

Recruiting
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06663384

Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain

Recruiting
Ages 50 to 64 · All sexes · Updated Sep 8, 2026 · NCT07674901

Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee

RecruitingPhase 2
Ages 21 to 75 · All sexes · Updated Sep 4, 2026 · NCT04992624

Remote Tai Chi for Knee Osteoarthritis

Recruiting
Ages 50 to 100 · All sexes · Updated Sep 4, 2026 · NCT06384898

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

RecruitingPhase 2
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07641517

Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

Recruiting
Ages 50 to 100 · All sexes · Updated Sep 2, 2026 · NCT06887829

A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee

RecruitingPhase 2
Ages 45 to 80 · All sexes · Updated Aug 25, 2026 · NCT06884865

Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection

Recruiting
Ages 18 to 70 · All sexes · Updated Aug 24, 2026 · NCT05985785

Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT07639060

Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.

RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07151417

Diet Interventions: Remitted and Evaluated as Complementary Treatments for Pain

Recruiting
Ages 40 to 75 · All sexes · Updated Aug 12, 2026 · NCT05785884

Sleep TO Prevent Post-surgical Pain

Recruiting
Ages 60 and older · All sexes · Updated Aug 7, 2026 · NCT06976138

Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation

Recruiting
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06407427

The Osteoarthritis Prevention Study

RecruitingHealthy volunteers welcome
Ages 50 and older · Women · Updated Jul 23, 2026 · NCT05946044

Innovations in Genicular Outcomes Registry

RecruitingObservational study
All ages · All sexes · Updated Jul 23, 2026 · NCT05495334

Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA

RecruitingPhase 2
Ages 45 to 75 · All sexes · Updated Jul 17, 2026 · NCT05839535

MOTION Clinical Trial

Recruiting
All ages · All sexes · Updated Jul 14, 2026 · NCT06843980

Genicular Artery Embolization for Knee Osteoarthritis

Recruiting
Ages 40 to 80 · All sexes · Updated Jul 14, 2026 · NCT07537153

Persona Revision Knee System Outcomes

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT04821154

Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT06902285

BioPoly® Partial Resurfacing Knee Implant IDE

Recruiting
Ages 30 to 65 · All sexes · Updated Jul 8, 2026 · NCT06915363

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.