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Knee Osteoarthritis clinical trials recruiting in the U.S.

81 studies for Knee Osteoarthritis are recruiting participants at sites across the United States.

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Recently updated studies

IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success

Recruiting
Ages 40 and older · All sexes · Updated Nov 12, 2026 · NCT07494838

BioPoly® Partial Resurfacing Knee Implant IDE

Recruiting
Ages 30 to 65 · All sexes · Updated Nov 12, 2026 · NCT06915363

Effect of Anti-inflammatory Diet in Osteoarthritis

Recruiting
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT06080347

Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis

Recruiting
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT05559463

A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07919678

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT05986292

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

RecruitingPhase 2
Ages 40 and older · All sexes · Updated Nov 4, 2026 · NCT07641517

Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

RecruitingPhase 2
Ages 40 to 80 · All sexes · Updated Oct 30, 2026 · NCT06859164

Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain

Recruiting
Ages 50 to 64 · All sexes · Updated Oct 27, 2026 · NCT07674901

Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

Recruiting
Ages 50 to 100 · All sexes · Updated Oct 26, 2026 · NCT06887829

Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance

RecruitingPhase 4
Ages 45 to 80 · All sexes · Updated Oct 21, 2026 · NCT07759336

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P)

RecruitingPhase 3
Ages 40 to 80 · All sexes · Updated Oct 16, 2026 · NCT07219771

Preventing Injured Knees From osteoArthritis: Severity Outcomes

RecruitingPhase 2
Ages 18 to 45 · All sexes · Updated Oct 15, 2026 · NCT06096259

Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes

RecruitingPhase 4
Ages 40 and older · All sexes · Updated Oct 13, 2026 · NCT06478186

Remote Tai Chi for Knee Osteoarthritis

Recruiting
Ages 50 to 100 · All sexes · Updated Oct 8, 2026 · NCT06384898

Assessing the Association Between WBCT PFJ Morphological Metrics and Knee Symptoms

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07472088

taVNS in Veterans With Knee OA (AVAHCS)

Recruiting
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT07804199

ARVIS TKA vs Conventional TKA

Recruiting
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06663384

Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee

RecruitingPhase 2
Ages 21 to 75 · All sexes · Updated Sep 4, 2026 · NCT04992624

A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee

RecruitingPhase 2
Ages 45 to 80 · All sexes · Updated Aug 25, 2026 · NCT06884865

Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection

Recruiting
Ages 18 to 70 · All sexes · Updated Aug 24, 2026 · NCT05985785

Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT07639060

Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.

RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07151417

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.