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Knee Osteoarthritis clinical trials recruiting in the U.S.
80 studies for Knee Osteoarthritis are recruiting participants at sites across the United States.
Cities with the most studies
- Chicago, IL15 studies
- Birmingham, AL6 studies
- Phoenix, AZ6 studies
- Boston, MA5 studies
- New York City, NY5 studies
- Deltona, FL5 studies
- Durham, NC5 studies
- Baltimore, MD4 studies
- Bellevue, WA4 studies
- Indio, CA4 studies
- Omaha, NE4 studies
- San Diego, CA4 studies
- New Orleans, LA4 studies
- Atlanta, GA4 studies
- Cleveland, OH4 studies
- Miami, FL4 studies
- San Antonio, TX4 studies
- New Haven, CT4 studies
- Jacksonville, FL3 studies
- Ann Arbor, MI3 studies
- O'Fallon, MO3 studies
- Springfield, MO3 studies
- Troy, MI3 studies
- Mountain View, CA3 studies
- Altoona, PA3 studies
- Dayton, OH3 studies
- Newton, MA3 studies
- Orlando, FL3 studies
- Tulsa, OK3 studies
- Rochester, NY3 studies
By state
- Alabama6 studies
- Arizona7 studies
- Arkansas3 studies
- California20 studies
- Connecticut6 studies
- Florida14 studies
- Georgia6 studies
- Illinois19 studies
- Indiana3 studies
- Kansas3 studies
- Louisiana4 studies
- Maryland5 studies
- Massachusetts10 studies
- Michigan8 studies
- Missouri5 studies
- Nebraska5 studies
- New York10 studies
- North Carolina10 studies
- Ohio8 studies
- Oklahoma3 studies
- Pennsylvania8 studies
- South Carolina3 studies
- Tennessee4 studies
- Texas10 studies
- Virginia4 studies
- Washington5 studies
Recently updated studies
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT05986292ARVIS TKA vs Conventional TKA
Recruiting
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06663384Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain
Recruiting
Ages 50 to 64 · All sexes · Updated Sep 8, 2026 · NCT07674901Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
RecruitingPhase 2
Ages 21 to 75 · All sexes · Updated Sep 4, 2026 · NCT04992624Remote Tai Chi for Knee Osteoarthritis
Recruiting
Ages 50 to 100 · All sexes · Updated Sep 4, 2026 · NCT06384898Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
Recruiting
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07804446A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
RecruitingPhase 2
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07641517Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
Recruiting
Ages 50 to 100 · All sexes · Updated Sep 2, 2026 · NCT06887829A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
RecruitingPhase 2
Ages 45 to 80 · All sexes · Updated Aug 25, 2026 · NCT06884865Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection
Recruiting
Ages 18 to 70 · All sexes · Updated Aug 24, 2026 · NCT05985785Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT07639060Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07151417AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07509307Diet Interventions: Remitted and Evaluated as Complementary Treatments for Pain
Recruiting
Ages 40 to 75 · All sexes · Updated Aug 12, 2026 · NCT05785884Sleep TO Prevent Post-surgical Pain
Recruiting
Ages 60 and older · All sexes · Updated Aug 7, 2026 · NCT06976138Evaluating the Efficacy of a Mobile Application in Postoperative Rehabilitation
Recruiting
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06407427The Osteoarthritis Prevention Study
RecruitingHealthy volunteers welcome
Ages 50 and older · Women · Updated Jul 23, 2026 · NCT05946044Innovations in Genicular Outcomes Registry
RecruitingObservational study
All ages · All sexes · Updated Jul 23, 2026 · NCT05495334Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA
RecruitingPhase 2
Ages 45 to 75 · All sexes · Updated Jul 17, 2026 · NCT05839535MOTION Clinical Trial
Recruiting
All ages · All sexes · Updated Jul 14, 2026 · NCT06843980Genicular Artery Embolization for Knee Osteoarthritis
Recruiting
Ages 40 to 80 · All sexes · Updated Jul 14, 2026 · NCT07537153Persona Revision Knee System Outcomes
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT04821154A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT07481630Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT06902285BioPoly® Partial Resurfacing Knee Implant IDE
Recruiting
Ages 30 to 65 · All sexes · Updated Jul 8, 2026 · NCT06915363From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.