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Knee Osteoarthritis clinical trials recruiting in the U.S.
81 studies for Knee Osteoarthritis are recruiting participants at sites across the United States.
Cities with the most studies
- Chicago, IL15 studies
- Birmingham, AL7 studies
- Atlanta, GA6 studies
- Phoenix, AZ6 studies
- San Antonio, TX5 studies
- Durham, NC5 studies
- Boston, MA5 studies
- New York City, NY5 studies
- New Orleans, LA5 studies
- Miami, FL5 studies
- Deltona, FL5 studies
- Omaha, NE4 studies
- San Diego, CA4 studies
- Cleveland, OH4 studies
- New Haven, CT4 studies
- Altoona, PA4 studies
- Bellevue, WA4 studies
- Indio, CA4 studies
- Baltimore, MD4 studies
- Jacksonville, FL4 studies
- Orlando, FL3 studies
- Salt Lake City, UT3 studies
- Ann Arbor, MI3 studies
- Tampa, FL3 studies
- Troy, MI3 studies
- Dayton, OH3 studies
- Newton, MA3 studies
- The Villages, FL3 studies
- O'Fallon, MO3 studies
- Ocala, FL3 studies
- Rochester, NY3 studies
- Springfield, MO3 studies
- Tulsa, OK3 studies
- Roswell, GA3 studies
- Los Angeles, CA3 studies
- Dallas, TX3 studies
- Wilmington, NC3 studies
- Mountain View, CA3 studies
By state
- Alabama7 studies
- Arizona10 studies
- Arkansas3 studies
- California23 studies
- Connecticut6 studies
- Florida16 studies
- Georgia8 studies
- Illinois19 studies
- Indiana3 studies
- Kansas4 studies
- Kentucky3 studies
- Louisiana5 studies
- Maryland5 studies
- Massachusetts10 studies
- Michigan9 studies
- Missouri5 studies
- Nebraska5 studies
- New York10 studies
- North Carolina12 studies
- Ohio8 studies
- Oklahoma4 studies
- Pennsylvania8 studies
- South Carolina3 studies
- Tennessee4 studies
- Texas11 studies
- Utah3 studies
- Virginia3 studies
- Washington5 studies
Recently updated studies
IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success
Recruiting
Ages 40 and older · All sexes · Updated Nov 12, 2026 · NCT07494838BioPoly® Partial Resurfacing Knee Implant IDE
Recruiting
Ages 30 to 65 · All sexes · Updated Nov 12, 2026 · NCT06915363Effect of Anti-inflammatory Diet in Osteoarthritis
Recruiting
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT06080347Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis
Recruiting
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT05559463A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07919678A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT05986292A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
RecruitingPhase 2
Ages 40 and older · All sexes · Updated Nov 4, 2026 · NCT07641517A Study to Learn About Berobenatide Given Once Weekly in Adults With Knee Osteoarthritis and Overweight or Obesity With or Without Type 2 Diabetes (VESPER-OA 2)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07915609Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis
RecruitingPhase 2
Ages 40 to 80 · All sexes · Updated Oct 30, 2026 · NCT06859164Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain
Recruiting
Ages 50 to 64 · All sexes · Updated Oct 27, 2026 · NCT07674901Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial
Recruiting
Ages 50 to 100 · All sexes · Updated Oct 26, 2026 · NCT06887829Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance
RecruitingPhase 4
Ages 45 to 80 · All sexes · Updated Oct 21, 2026 · NCT07759336A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P)
RecruitingPhase 3
Ages 40 to 80 · All sexes · Updated Oct 16, 2026 · NCT07219771Preventing Injured Knees From osteoArthritis: Severity Outcomes
RecruitingPhase 2
Ages 18 to 45 · All sexes · Updated Oct 15, 2026 · NCT06096259Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes
RecruitingPhase 4
Ages 40 and older · All sexes · Updated Oct 13, 2026 · NCT06478186Remote Tai Chi for Knee Osteoarthritis
Recruiting
Ages 50 to 100 · All sexes · Updated Oct 8, 2026 · NCT06384898Assessing the Association Between WBCT PFJ Morphological Metrics and Knee Symptoms
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07472088taVNS in Veterans With Knee OA (AVAHCS)
Recruiting
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT07804199ARVIS TKA vs Conventional TKA
Recruiting
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06663384Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
Recruiting
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07804446Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
RecruitingPhase 2
Ages 21 to 75 · All sexes · Updated Sep 4, 2026 · NCT04992624A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
RecruitingPhase 2
Ages 45 to 80 · All sexes · Updated Aug 25, 2026 · NCT06884865Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection
Recruiting
Ages 18 to 70 · All sexes · Updated Aug 24, 2026 · NCT05985785Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT07639060Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07151417From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.