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Effect of Gerofit Exercise on Cognition in Older Veterans
Relationship of Exercise Frequency, Intensity, and Fitness to Improved Cognition and Biomarkers in Gerofit Participants
Who can join
Ages 65 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * All Veterans eligible for VA Gerofit program 65 years and older * Clearance by PCP to participate in Gerofit exercise program Exclusion Criteria: * Inability to perform ADLs * Significant cognitive impairment * Inability to function independently without assistance * Unstable angina; proliferative diabetic retinopathy * Oxygen dependent * Unwillingly to commute and/or not able to provide own transportation to Gerofit * Incontinence * Open wounds * Volatile behavioral issue or unable to work successfully in a group environment/setting * Active substance abuse * Homelessness
About the study
Over 50% of the Veterans enrolled for VA health care are over the age of 65. Dementia prevalence increases with age, and with the increase in the population of people ages 65 and older, the total number of people with dementia is also increasing. Older Veterans often have comorbid PTSD, major depression and traumatic brain injury so that they are at 2 to 5 times the risk for cognitive impairment and dementia compared to the general population. There is evidence that exercise interventions in sedentary older adults could improve both physical and cognitive function. However, there have been very few studies on the effects of exercise on cognition in older Veterans and do not reflect the broader ethnic and health-status diversity of Veterans. Thus, improved knowledge of the role of exercise on cognition as well as the predictive power of biomarkers could have a major beneficial impact on Veterans' functional independence and quality of life. The investigators hypothesize that participation in the VA Gerofit exercise program will improve cognitive function in older Veterans and that blood and muscle biomarkers will predict these improvements.
What is being tested
- Gerofit exercise (behavioral)
- Health education (behavioral)
Sponsor: VA Office of Research and Development · Participants: 150 · Started: Apr 1, 2024
Contact the study team
- Cathy C Lee, MD · Phone: (310) 268-4110
Official record on ClinicalTrials.gov — NCT06107842
Locations in the U.S.
| California | VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles |
| Maryland | Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.