🔎 Trials Near Me

Home › Type 2 Diabetes › NCT06120881

Precision Dosing of Metformin in Youth With T2D

RecruitingEarly phase 1Healthy volunteers welcome

Pilot Study of Precision Dosing of Metformin in Youth With Type 2 Diabetes (PRECISE_T2D)

Who can join

Ages 10 to 21 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Age 10-21 years
* Provider diagnosis of T2D
* Stable medication regimen for 2 weeks before screening visit (No addition or removal of medications and no more than 20% change in insulin dose)
* ≥ 1 month from T2D diagnosis
* Taking regular metformin (not extended-release formula)
* Ability to wear CGM for a total of 6 weeks while in the study.
* English or Spanish speakers.
* Willing to abide by recommendations and study procedures.
* Willing and able to sign the Informed Consent Form (ICF) and/or has a parent or guardian willing and able to sign the ICF.
* Participant and parent(s)/guardian(s) willingness to participate in all training sessions as directed by study staff. Written informed consent (and assent when applicable) obtained from subject or subject's legal representative and ability for subject to comply with the requirements of the study.

Exclusion Criteria:

* Pancreatic autoantibody positivity (GAD-65, insulin, IA-2, ICA 512, Zn-T8).
* Known history of ongoing renal or hepatic disease.
* Known history of significant mental illness or developmental delay impacting the ability to complete study activities independently.

About the study

The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).

What is being tested

Sponsor: University of California, San Francisco · Participants: 20 · Started: Apr 25, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06120881

Locations in the U.S.

CaliforniaUCSF Benioff Children's Hospital Oakland, Pediatric Diabetes Clinic, Oakland
UCSF Benioff Children's Hospital San Francisco, Madison Clinic for Pediatric Diabetes, San Francisco

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.