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EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation
EXCLAMATORY: EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation TO Reduce Atrial Fibrillation Burden and Correlation With Exercise CapacitY Longitudinal Study
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Age ≥18 years * Diagnosis of paroxysmal AF * Left ventricular ejection fraction ≥50% * Scheduled for catheter ablation * Able to speak, hear, and read English * Willing and able to provide informed consent Exclusion Criteria: * Persistent or permanent AF * Prior ablation (catheter based or surgical) for AF * Significant sinus node dysfunction * Implanted pacemaker or defibrillator * Contraindication to or inability to complete cardiovascular magnetic resonance study * Contraindication to or inability to complete exercise testing * Chronic kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2 * Severe left ventricular hypertrophy * Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to: * Hypertrophic cardiomyopathy * Cardiac amyloidosis * Constrictive pericarditis * Pulmonary arterial hypertension * Prior cardiac surgery * Active pregnancy
About the study
Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).
What is being tested
- Self- Report Evaluation-Duke Activity Status Index (behavioral)
- Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire (behavioral)
- Cardiopulmonary exercise test (CPET) (diagnostic test)
- Transthoracic echocardiogram (diagnostic test)
- Ambulatory cardiac rhythm assessment (diagnostic test)
- Cardiovascular magnetic resonance (CMR) (diagnostic test)
Sponsor: Virginia Commonwealth University · Participants: 50 · Started: Dec 26, 2024
Contact the study team
- Pamela Grizzard · Phone: 804-628-6234
- Melissa Sears · Phone: 804-828-1601
Official record on ClinicalTrials.gov — NCT06212791
Locations in the U.S.
| Virginia | Virginia Commonwealth University, Richmond |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.