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Atrial Fibrillation clinical trials recruiting in the U.S.

107 studies for Atrial Fibrillation are recruiting participants at sites across the United States.

Atrial fibrillation (AF or AFib) is the most common type of arrhythmia (irregular heartbeat). Read about symptoms and treatment.

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Recently updated studies

Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation

Recruiting
Ages 40 and older · All sexes · Updated Nov 13, 2026 · NCT06938412

Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual)

RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Nov 13, 2026 · NCT06844227

ReVeRA-301: Etripamil in Atrial Fibrillation Phase 3

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06716021

PULSED AF Post-Approval Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06578104

Intracardiac Echocardiography Guided Watchman Device Implant

Recruiting
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT06007872

Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07175428

Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07626411

The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

RecruitingPhase 3
Ages 22 to 85 · All sexes · Updated Nov 3, 2026 · NCT05836987

Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

RecruitingObservational study
Ages 18 to 110 · All sexes · Updated Oct 29, 2026 · NCT05724121

A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07217067

BOdygUardian MOnitoriNg for ReCurrencE of AF

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07671677

Globe Registry: Globe® Pulsed Field System Registry Study for Treating Patients With Symptomatic Atrial Fibrillation

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT07651852

Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation

Recruiting
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT07575269

Repeatable Evaluation of Functional Intra-procedural Signals for Effect in Pulsed Field Ablation REFINE-PFA

RecruitingObservational study
Ages 21 and older · All sexes · Updated Oct 21, 2026 · NCT07275151

Pericardiotomy in Cardiac Surgery

Recruiting
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT06486636

Comparison of Two Pulse Field Ablation Systems for AF Ablation

Recruiting
Ages 18 to 89 · All sexes · Updated Oct 20, 2026 · NCT07883629

Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.

RecruitingObservational study
Ages 18 to 79 · All sexes · Updated Oct 20, 2026 · NCT04703166

A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation

RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Oct 20, 2026 · NCT07625215

Elite AF IDE Trial (Elite AF)

Recruiting
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07287436

Bachmann's Bundle Versus Right Atrial Appendage Pacing

Recruiting
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07874763

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.