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Atrial Fibrillation clinical trials recruiting in the U.S.

108 studies for Atrial Fibrillation are recruiting participants at sites across the United States.

Atrial fibrillation (AF or AFib) is the most common type of arrhythmia (irregular heartbeat). Read about symptoms and treatment.

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Recently updated studies

The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

RecruitingPhase 3
Ages 22 to 85 · All sexes · Updated Sep 28, 2026 · NCT05836987

Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07626411

Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07175428

A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07217067

Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06376916

Optimal Anti-Thrombotic Management Following Percutaneous Left Atrial Appendage Occlusion

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07840365

Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation

Recruiting
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07575269

Comparing the Safety and Efficacy of Apixaban and Rivaroxaban

RecruitingPhase 4
Ages 22 and older · All sexes · Updated Sep 23, 2026 · NCT06953726

ReVeRA-301: Etripamil in Atrial Fibrillation Phase 3

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06716021

Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT04088071

PULSED AF Post-Approval Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06578104

The Fourth Left Atrial Appendage Occlusion Study

Recruiting
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05963698

Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT00921986

Post-ablation Alcohol Impacts Arrhythmia Recurrence, Quality of Life and Cognition in AF

Recruiting
Ages 18 to 85 · All sexes · Updated Sep 14, 2026 · NCT05510167

Novel Technologies to Improve Echocardiographic Estimates of Left Ventricular Filling Pressure in Heart Failure Combined With Atrial Fibrillation

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07436299

CellFX® Nanosecond Pulsed Field Ablation (nsPFA)™ Cardiac Surgery Clamp System to Treat Atrial Fibrillation

Recruiting
Ages 18 to 85 · All sexes · Updated Sep 9, 2026 · NCT06959121

High-resolution MRI of Atrial Fibrillation Patients Prior to Focal Impulse and Rotor Modulation (FIRM) Ablation

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT03444337

A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation

RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Sep 9, 2026 · NCT07625215

Evaluation of 4D Intracardiac Echocardiography (ICE) During Structural Heart and Electrophysiology Procedures

Recruiting
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07806890

Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

RecruitingObservational study
Ages 22 and older · All sexes · Updated Sep 8, 2026 · NCT07122947

BOdygUardian MOnitoriNg for ReCurrencE of AF

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07671677

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.