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A Computerized Depression Intervention in Veterans

A Randomized Controlled Trial of Deprexis; Evaluation of A Computerized Intervention to Decrease Depression and Restore Functioning in Veterans

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

Potential participants include male and female Veterans of all races/ethnicities who are:

* able to comprehend and sign the informed consent form
* have reliable access to the internet and a computer, tablet and/or smartphone
* exhibit mild or moderate, but not very severe, levels of depression
* stable on psychotropic medications

Exclusion Criteria:

Aim 1 and Aim 2: Veterans will be excluded from study participation if they:

* endorse any positive symptoms of a psychotic disorder
* screen positive for Bipolar I Disorder
* report current suicidal risk

About the study

Depressive symptoms are common among Veterans and associated with significant impairment. Timely intervention has the potential to improve mental health outcomes and restore functioning. Interventions delivered through the internet can be completed remotely at any time, and thus minimize burden on Veterans, however the research examining their utility in Veterans is limited. This proposed project will examine Deprexis, a self-guided internet-delivered intervention, which targets depressive symptoms and associated functional impairments. Interviews will be conducted to gain insight into Veterans' perceptions, needs, and preferences vis-a-vis Deprexis, with results informing a randomized controlled trial. Here an 8-week course of Deprexis will be compared to a treatment-as-usual (TAU) control condition to establish if Deprexis is acceptable and effective for Veterans with mild to moderate depressive symptoms. Veterans engaged in Deprexis are hypothesized to show improvements on measures of functioning and decreases in depressive symptoms compared to the TAU control group. The proposed work has great clinical utility, as it could provide a readily accessible, high-quality intervention for the many Veterans suffering from depressive symptoms, with the potential to improve functioning and long-term outcomes.

What is being tested

• Deprexis (behavioral)

Sponsor: VA Office of Research and Development · Participants: 152 · Started: May 1, 2024

Contact the study team

• Rahel R Pearson, PhD · Phone: (254) 297-5155
• Suzannah K Creech, PhD · Phone: (254) 297-3025

Official record on ClinicalTrials.gov — NCT06217198

Locations in the U.S.

Conditions

• Depression

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.