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Magnesium and Riboflavin Treatment for Post-Concussion Headache

Who can join

Ages 18 to 40 · All sexes

Inclusion Criteria:

* Seen at University of Virginia Student Health and Wellness Center or Emergency Department for Initial Visit for Concussion;
* Less than 3 days have elapsed since their injury;
* Able to swallow capsules

Exclusion Criteria:

* Concussion complicated by cranial bleed, skull fracture, additional severe injury;
* Kidney disfunction or failure;
* Significant gastro-intestinal dysfunction;
* Varsity Athlete;
* Two or more previous concussions;
* Women who are pregnant or breast feeding;
* Taking tetracycline, fluoroquinolone, iron digoxin, chlorpromazine or penicillamine

About the study

This clinical trial will try to determine if the supplements magnesium and riboflavin will reduce the pain and duration of headaches in persons diagnosed with a concussion. The participant will be randomized to either active magnesium and riboflavin capsules or placebo (inert) capsules. The capsules will be taken once a day for 14 days. The participant will also complete a short diary form for the 14 days and will have 3 follow up visits either by telephone or in person.

What is being tested

• magnesium and riboflavin supplement (drug)

Sponsor: University of Virginia · Participants: 108 · Started: Feb 10, 2020

Contact the study team

• Stephanie Hartman, MD · Phone: 434-924-5362
• Karen Ahern, BSN MBA · Phone: 4340924-1549

Official record on ClinicalTrials.gov — NCT06260072

Locations in the U.S.

Conditions

• Concussion
• Headache

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.