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Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

Recruiting

HOPE in Action Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes

Who can join

Ages 18 and older · All sexes

Full eligibility criteria

Inclusion Criteria:

* Participant meets local criteria for kidney transplant.
* Participant is able to understand and provide informed consent.
* Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA.
* Participant is ≥ 18 years old.
* HIV-1 RNA \< 50 copies/mL. Viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements \> 200 copies/mL.
* Participant is not suffering from significant wasting (e.g. body mass index \<21) thought to be related to HIV disease.

Exclusion Criteria:

* Participant has prior progressive multifocal leukoencephalopathy (PML), cryptosporidiosis of \> 1 month, or primary central nervous system (CNS) lymphoma.
* Participant is pregnant or breastfeeding.
* Past or current medical problems or findings from medical history, physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.

About the study

This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.

What is being tested

HIV D+/R+ (other)
HIV D-/R+ (other)

Sponsor: Johns Hopkins University · Participants: 200 · Started: May 22, 2024

Contact the study team

Christine Durand, MD · Phone: 410-614-6702

Official record on ClinicalTrials.gov — NCT06263426

Locations in the U.S.

Alabama	University of Alabama at Birmingham, Birmingham
California	University of California, Davis, Sacramento University of California, San Diego, San Diego University of California, San Francisco, San Francisco
Florida	Mayo Clinic Florida, Jacksonville
Illinois	Northwestern University, Chicago Rush University Medical Center, Chicago
Louisiana	Ochsner Clinic Foundation, New Orleans
Maryland	Johns Hopkins University, Baltimore
Massachusetts	Massachusetts General Hospital, Boston
Missouri	Washington University St. Louis Barnes Jewish Hospital, St Louis
New York	Columbia University, New York Icahn School of Medicine at Mt. Sinai, New York New York University, New York Weill Cornell Medical Center, New York (Not yet recruiting)
Pennsylvania	University of Pennsylvania, Philadelphia University of Pittsburgh Medical Center, Pittsburgh
Texas	Houston Methodist Research Institute, Houston

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.