Home › Sickle Cell Disease › NCT06290401
A Socio-ecological Approach for Improving Self-management in Adolescents With SCD
Who can join
Ages 13 to 21 · All sexes
Full eligibility criteria
Inclusion Criteria: * Patient of a participating SCD Clinic * Confirmed diagnosis of SCD * 13-21 years of age Exclusion Criteria: * Another chronic disease (which would complicate measurement of patient activation) * Non-English-speaking * Cognitive or psychiatric disorder that the physician or study therapists believe would impair study participation.
About the study
The goal of this clinical trial is to evaluate the impact of SCThrive (a behavioral self-management intervention) on patient activation, self-management behaviors, daily functioning, and emergency room visits in 260 adolescents and young adults with sickle cell disease (SCD) ages 13-21 receiving care at 1 of 4 pediatric SCD clinics.
The main question\[s\]it aims to answer are:
* Does SCThrive improve patient activation? * Does SCThrive improve self-management behaviors, daily functioning, and decrease emergency room visits? * Are any improvements maintained 3 months after treatment?
Participants will complete self-management related surveys before, after, and 3 months following their participation in an 8- week, virtual group intervention with an accompanying mobile app (SCThrive).
Researchers will compare outcomes for participants who receive SCThrive and participants who receive uniform standard care (SCHealthED which = standard of care plus SCD educational text messages) to see if there are differences in patient activation, self-management behaviors, daily functioning, and emergency room visits.
What is being tested
- SCThrive (behavioral)
- SCHealthED (other)
Sponsor: Children's Hospital Medical Center, Cincinnati · Participants: 310 · Started: Feb 3, 2025
Contact the study team
- Ama Wilson, MPH · Phone: 15136365380
Official record on ClinicalTrials.gov — NCT06290401
Locations in the U.S.
| Delaware | Nemours Children's Health, Wilmington (Not yet recruiting) |
| Georgia | Children's Healthcare of Atlanta, Atlanta (Not yet recruiting) |
| Ohio | Cincinnati Children's Hospital Medical Center, Cincinnati |
| Pennsylvania | Children's Hospital of Philadelphia, Philadelphia (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.