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Adversity, Brain and Opioid Use Study
A Mechanistic Investigation of Risk Factors for Opioid Use Disorder: Examining Hippocampal-based Context-dependent Learning and Memory Associated With Adverse Childhood Experiences
Who can join
Ages 18 to 55 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria for all groups: * Fluent in English * Able to give informed consent * Normal/corrected-to-normal vision and hearing Inclusion Criteria for Opioid Use Disorder (OUD) group: * Diagnosis of OUD * Be actively receiving buprenorphine (BUP) for opioid agonist therapy * Be free from illicit substance use for at least 2 weeks * The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol) Inclusion Criteria for the BUP control group: * Taking BUP for chronic pain * No Substance Use Disorder (including OUD) * The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol) Inclusion Criteria for Healthy participant group: * Not taking BUP * Free of any psychiatric or major medical conditions Exclusion Criteria for all groups: * Pregnancy * Significant medical or neurologic conditions (e.g., stroke, seizures, multiple sclerosis) * Actively suicidal * Contraindication for MRI * Inability to tolerate small, enclosed spaces without anxiety or unable to fit comfortably in the MRI scanner * Life history of schizophrenia, learning disability, attention deficit disorder, or pervasive developmental disorder * Use of substances or prescription medications that could interfere with measures of interest (per protocol) * Unable to provide informed consent * Participants who have completed other studies in our lab involving learning and memory assessments with the same/similar tasks used here (HUM00230585, HUM00121812) will not be eligible to complete the current study, due to possible learning/practice effects
About the study
The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine.
What is being tested
- Magnetic Resonance Imaging (MRI) (other)
- Computer Tasks (behavioral)
Sponsor: University of Michigan · Participants: 185 · Started: Jan 9, 2025
Contact the study team
- Aml Almamri · Phone: 734-232-0190
Official record on ClinicalTrials.gov — NCT06355778
Locations in the U.S.
| Michigan | University of Michigan, Ann Arbor |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.