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Switch or Quit R01
Non-cigarette Tobacco Products as Harm Reduction Tools in Smokers Who Failed to Quit With Traditional Methods
Who can join
Ages 21 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria * Adults 21+ who previously had a quit attempt using FDA-approved pharmacotherapy. * Interest in reducing harms from tobacco use or quitting smoking Exclusion Criteria * Pregnant, breastfeeding, or trying to become pregnant. * Household member currently enrolled in the study * Planning to move out of the area within the next 7 months
About the study
This study evaluates whether non-cigarette tobacco products (e-cigarettes) can help smokers quit smoking as compared to traditional quit methods (nicotine replacement therapy or varenicline/Chantix). Participants in this study will be randomly assigned to one of two groups, then will have a choice between the offered products of that group. Participants in the e-cigarette group will have a choice of e-cigarette brand and flavor. Participants in the medication group will have choice between nicotine replacement therapy (patches and lozenges) or varenicline, also known as Chantix. Participation will last 6 months and will include weekly phone calls for the initial 7-weeks plus a 11-week phone call and a 6-month follow-up visit. Participants will also complete electronic daily diaries during the first 7-weeks.
What is being tested
- Switching to E-Cigarette (behavioral)
- Switching using Medication (behavioral)
Sponsor: Medical University of South Carolina · Participants: 225 · Started: Jul 10, 2024
Contact the study team
- Tracy Smith, PhD · Phone: (843)-792-5164
- Hana Thamer · Phone: (843)-876-2430
Official record on ClinicalTrials.gov — NCT06373679
Locations in the U.S.
| South Carolina | Medical Univeristy of South Carolina, Charleston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.