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Smoking clinical trials recruiting in the U.S.
54 studies for Smoking are recruiting participants at sites across the United States.
There's no way around it. Smoking is bad for your health. Learn the effects of smoking (how smoking harms nearly every organ) and how to quit.
Cities with the most studies
- Philadelphia, PA6 studies
- Charleston, SC5 studies
- Buffalo, NY4 studies
- New York City, NY4 studies
- Atlanta, GA4 studies
- Baltimore, MD3 studies
- Edison, NJ3 studies
- Houston, TX3 studies
- Roanoke, VA3 studies
By state
- California6 studies
- Colorado3 studies
- Florida3 studies
- Georgia4 studies
- Illinois4 studies
- Maryland3 studies
- New Jersey3 studies
- New York9 studies
- North Carolina3 studies
- Oklahoma3 studies
- Pennsylvania6 studies
- South Carolina6 studies
- Texas4 studies
- Virginia4 studies
Recently updated studies
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
RecruitingHealthy volunteers welcome
Ages 21 and older ยท All sexes ยท Updated Nov 12, 2026 ยท NCT06264154E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
RecruitingPhase 2
Ages 21 to 75 ยท All sexes ยท Updated Nov 9, 2026 ยท NCT05722561A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System
RecruitingHealthy volunteers welcome
Ages 21 to 65 ยท All sexes ยท Updated Oct 22, 2026 ยท NCT07879638Generalized and Domain-Specific Episodic Thinking for Smoking Cessation
Recruiting
Ages 21 and older ยท All sexes ยท Updated Oct 13, 2026 ยท NCT07158749E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness
Recruiting
Ages 21 and older ยท All sexes ยท Updated Sep 29, 2026 ยท NCT05815199Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 45 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT03721822Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)
Recruiting
Ages 50 to 80 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT07711691Semaglutide for Post-Smoking Cessation Weight Management
RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 75 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT06173778Trauma-Informed Care for Smoking Cessation for Pregnancy
RecruitingHealthy volunteers welcome
Ages 18 and older ยท Women ยท Updated Sep 10, 2026 ยท NCT07129590Varenicline for Smoking Reduction in Veterans Not Ready To Quit
RecruitingPhase 4
Ages 21 and older ยท All sexes ยท Updated Aug 31, 2026 ยท NCT06966362Cardiovascular Effects of Very Low Nicotine Content Cigarettes
RecruitingEarly phase 1Healthy volunteers welcome
Ages 21 and older ยท All sexes ยท Updated Aug 28, 2026 ยท NCT05707871A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
RecruitingHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Aug 27, 2026 ยท NCT06693700Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
RecruitingHealthy volunteers welcome
Ages 21 and older ยท All sexes ยท Updated Aug 20, 2026 ยท NCT06678789A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
RecruitingHealthy volunteers welcome
Ages 21 and older ยท All sexes ยท Updated Aug 12, 2026 ยท NCT06118502The SMOKE Telehealth Study
Recruiting
Ages 18 and older ยท All sexes ยท Updated Aug 12, 2026 ยท NCT07743710Effects of Cannabidiol on Stress and Nicotine Withdrawal
RecruitingPhase 1
Ages 21 to 70 ยท All sexes ยท Updated Aug 10, 2026 ยท NCT07001930Maternal Smoking Cessation and Pediatric Obesity Prevention
RecruitingHealthy volunteers welcome
Ages 18 to 39 ยท Women ยท Updated Jul 30, 2026 ยท NCT03514602A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers
RecruitingHealthy volunteers welcome
Ages 21 to 65 ยท All sexes ยท Updated Jul 17, 2026 ยท NCT07710820Switch or Quit R01
RecruitingHealthy volunteers welcome
Ages 21 and older ยท All sexes ยท Updated Jul 13, 2026 ยท NCT063736795-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
RecruitingPhase 2Healthy volunteers welcome
Ages 21 and older ยท All sexes ยท Updated Jun 29, 2026 ยท NCT05452772PASCAL Feasibility Study
Recruiting
Ages 21 and older ยท All sexes ยท Updated Jun 24, 2026 ยท NCT07301151Prevention of Postpartum Smoking Relapse and Related Health Consequences by Breastfeeding Promotion
RecruitingHealthy volunteers welcome
Ages 18 and older ยท Women ยท Updated Jun 22, 2026 ยท NCT07661550Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
RecruitingHealthy volunteers welcome
Ages 21 and older ยท All sexes ยท Updated Jun 11, 2026 ยท NCT07199517Cigarette Filter Study
Recruiting
Ages 21 and older ยท All sexes ยท Updated Jun 5, 2026 ยท NCT07348679A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers
RecruitingHealthy volunteers welcome
Ages 21 to 65 ยท All sexes ยท Updated Jun 3, 2026 ยท NCT07598136From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.