Home › Abdominal Pain › NCT06381921

Objective Integrated Multimodal Electrophysiological Index for the Quantification of Visceral Pain

OIME - Objective Integrated Multimodal Electrophysiological Index for the Quantification of Visceral Pain

Who can join

Ages 18 to 50 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Participants need to be diagnosed with IBS by a healthcare provider according to Rome-III or -IV criteria, with a current report of abdominal pain.
* Men and women 18-50 years old
* Able to read and speak English
* Daily access to a computer with internet access.

Exclusion Criteria:

* Other chronic pains that are usually not comorbid with IBS, e.g., diabetic neuropathy, myofascial pain, low back pain, peripheral neuropathy etc.
* Celiac disease or inflammatory bowel disease
* Diabetes mellitus; d) Serious mental health conditions
* Women during pregnancy or within 3 months post-partum period
* Self- reported Regular use of opioids or other illicit substances.
* Participants who have had COVID-19 should be fully recovered, and will be asked if their medical provider has made any restriction on activities.

About the study

The objectives of the study are to 1) Conduct telemetric biosignals (EDA, ECG, and EMG) recording in healthy controls and IBS participants experiencing cutaneous and visceral pain; and 2) Validate the OIME index as a biomarker for quantifying pain in IBS participants and its capability to assess the treatment of IBS pain via an ambulatory trial.

What is being tested

• IBS-PPSM intervention (behavioral)

Sponsor: University of Connecticut · Participants: 120 · Started: Sep 8, 2025

Contact the study team

• Hugo F Posada-Quintero · Phone: 8604861556

Official record on ClinicalTrials.gov — NCT06381921

Locations in the U.S.

Conditions

• Abdominal Pain
• Irritable Bowel Syndrome

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.