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Irritable Bowel Syndrome clinical trials recruiting in the U.S.

29 studies for Irritable Bowel Syndrome are recruiting participants at sites across the United States.

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Recently updated studies

A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07545759

A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07545772

Home Transcutaneous Electrical Acustimulation (TEA)

RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT05519683

Mechanisms of Gulf War Illness

Recruiting
Ages 18 to 65 · All sexes · Updated Aug 19, 2026 · NCT05972291

Irritable Bowel Syndrome and Control Volunteers: Diet Challenge

RecruitingHealthy volunteers welcome
Ages 18 to 75 · All sexes · Updated Aug 12, 2026 · NCT06668922

Mucosal and Microbiota Changes During Acute Campylobacteriosis

RecruitingObservational study
Ages 18 to 80 · All sexes · Updated Aug 7, 2026 · NCT03223077

Defining Objective Markers of Compliance for Dietary Therapies in IBS

Recruiting
Ages 18 to 65 · All sexes · Updated Jun 22, 2026 · NCT07494968

Well-being in IBS: Strengths and Happiness (WISH) 2.0

Recruiting
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT06866106

Indiana University Gastrointestinal Motility Diagnosis Registry

RecruitingObservational study
All ages · All sexes · Updated Jun 16, 2026 · NCT04506593

Psyllium in Pediatric IBS

RecruitingPhase 2
Ages 12 to 17 · All sexes · Updated May 26, 2026 · NCT06639984

A Study Evaluating the Impact of Regular FODMAP-targeting Digestive Enzyme Blend Use on Gastrointestinal Symptoms in Individuals With Self-Reported Bloating

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT07591584

Fecal Microbiota Transplantation for IBS

RecruitingPhase 2
Ages 18 to 70 · Women · Updated May 8, 2026 · NCT05776914

A Prospective Trial of a Variable Compression System for Moderate to Severe Irritable Bowel Syndrome

Recruiting
Ages 18 to 60 · All sexes · Updated Apr 29, 2026 · NCT07540312

Efficacy of Rifaximin With NAC in IBS-D

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Apr 20, 2026 · NCT06727422

Home-based Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for IBS Pain

Recruiting
Ages 18 to 29 · All sexes · Updated Apr 13, 2026 · NCT06847360

Online Social Learning Program for Parents With Irritable Bowel Syndrome: Raising Resilient Children

Recruiting
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT05730491

Drug Interaction Potential of Pro-Inflammatory Conditions

RecruitingObservational study
Ages 12 to 99 · All sexes · Updated Jan 22, 2026 · NCT07360938

Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator

RecruitingEarly phase 1
Ages 18 to 70 · All sexes · Updated Dec 18, 2025 · NCT06684470

IBS Skin Patch Test Food Allergy Study

Recruiting
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT06288672

Diet and Motility in IBS

RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 18 · All sexes · Updated Dec 15, 2025 · NCT07283341

Visible Abdominal Distension

RecruitingHealthy volunteers welcome
Ages 18 to 80 · All sexes · Updated Oct 31, 2025 · NCT06369753

Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 19, 2025 · NCT05754190

Objective Integrated Multimodal Electrophysiological Index for the Quantification of Visceral Pain

RecruitingHealthy volunteers welcome
Ages 18 to 50 · All sexes · Updated Sep 15, 2025 · NCT06381921

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.