Home › Traumatic Brain Injury › NCT06465290

Promoting Neuroplastic Changes of Patients With TBI

Who can join

Ages 30 to 85 · All sexes

Inclusion Criteria:

* Acute first time unilateral hemispheric stroke (hemorrhagic or ischemic stroke, 24 hours after admission to 1 month post-stroke at the start of the proposed treatment)
* Hemiplegia or hemiparesis
* 0≤Manual Muscle Testing (MMT)\<=2
* Age 30-85
* Ankle impairments including stiff calf muscles and/or inadequate dorsiflexion

Exclusion Criteria:

* Medically not stable
* Associated acute medical illness that interferes with ability to training and exercise
* No impairment or very mild ankle impairment of ankle
* Severe cardiovascular problems that interfere with ability to perform moderate movement exercises
* Cognitive impairment or aphasia with inability to follow instructions
* Severe pain in legs
* Severe ankle contracture greater than 15° plantar flexion (when pushing ankle to dorsiflexion)
* Pressure ulcer, recent surgical incision or active skin disease with open wounds present below knee

About the study

This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage post-TBI including patients who are paralyzed with no motor output. The early acute TBI rehabilitation device will be evaluated in this clinical trial.

What is being tested

• Motor relearning training with wearable ankle robot (device)
• Passive stretching with wearable ankle robot (device)
• Gamed-based active movement training with wearable ankle robot (device)
• Passive movement with limited wearable ankle robot (device)
• Active movement training with limited wearable ankle robot (device)
• Ankle/Wrist torque and motion measurement with limited wearable ankle/wrist robot (device)

Sponsor: University of Maryland, Baltimore · Participants: 100 · Started: Jul 16, 2026

Contact the study team

• Soh-Hyun Hur · Phone: 410 706-8625

Official record on ClinicalTrials.gov — NCT06465290

Locations in the U.S.

Conditions

• Traumatic Brain Injury
• Paraplegia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.