Home › Opioid Overdose › NCT06466005

UnityPhilly Response App for Overdose Reversal

UnityPhilly Response App for Overdose Reversal: Assessing Citywide Effectiveness and Sustainability

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* owning a smartphone with a data package;
* living or working in one of three identified Philadelphia neighborhoods;
* aged 18 or older.

Exclusion Criteria:

* persons aged under 18 years of age

About the study

The goal of this clinical trial is to discover if an overdose prevention app (UnityPhilly) can encourage citizen responders to respond and prevent opioid overdoses using the UnityPhilly app. The main hypotheses to answer are:

Hypothesis 1: UnityPhilly signal rates relative to EMS calls will increase over time. The primary outcome will be assessed as the total number of overdoses signaled by participants relative to all overdose-related EMS calls, per year.

Hypothesis 2: The number of cases where a nearby UnityPhilly participant successfully reverses an overdose with naloxone will increase over time. The primary outcome will be assessed as the number of successful reversals relative to the total number of responder arrivals, per year.

Participants will be supplied with the UnityPhilly app, training on how to use the app and respond to an opioid overdose using naloxone, and respond to follow up surveys about their experiences.

What is being tested

• UnityPhilly app (other)

Sponsor: Drexel University · Participants: 450 · Started: Sep 16, 2025

Contact the study team

• Stephen Lankenau, PhD · Phone: 323-326-6438

Official record on ClinicalTrials.gov — NCT06466005

Locations in the U.S.

Conditions

• Opioid Overdose

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.