The Avenues Study: Dual Use Cessation

RecruitingPhase 4

Dual Use Cessation: A MOST Screening Trial to Identify Effective Interventions to Help People Who Smoke and Vape

Who can join

Ages 21 and older · All sexes

Full eligibility criteria

Inclusion Criteria:

* Able to read and communicate in English
* Willing to set a quit date to quit smoking cigarettes in the next 30 days
* Willing and medically able to use varenicline and nicotine patches
* Smoking ≥ 5 cigarettes per day for the past 6 months
* Vaping weekly for at least 6 months
* Willing to stop using nicotine replacement or varenicline
* Willing to stop using bupropion (i.e., Wellbutrin, Zyban) if they are currently using it only for smoking cessation
* Saliva cotinine \>20 ng/ml
* US resident
* Own a Smartphone to use and download an app to record data
* have a working email so that they can receive links for video visits

Exclusion Criteria:

* Currently in treatment for psychosis or bipolar disorder
* If they are currently taking bupropion for non-smoking cessation reasons (e.g., Wellbutrin for depression)
* Currently pregnant or breastfeeding. If a participant becomes pregnant while in the study, they will be allowed to continue in the study but will no longer receive study medications. They will also be asked to return any unused study medications.

About the study

The overarching goal of this research is to determine the most effective approach for helping dual users of cigarettes and electronic nicotine delivery systems (ENDS) quit smoking. 500 participants will be enrolled and can expect to be on study for 12 months.

What is being tested

Varenicline (drug)
Nicotine patch (drug)
Dual Focused Cessation Counseling (behavioral)
Smoking Focused Cessation Counseling (behavioral)
Counseling Intensity: 1 Session (other)
Counseling Intensity: 4 Sessions (other)

Sponsor: University of Wisconsin, Madison · Participants: 500 · Started: Sep 24, 2024

Contact the study team

Mark Zehner · Phone: 608-262-7568

Official record on ClinicalTrials.gov — NCT06474299

Locations in the U.S.

Wisconsin

University of Wisconsin-Madison School of Medicine and Public Health, Madison

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.