Sleep Restriction and Parental History of Hypertension

Inclusion Criteria

* Healthy adults aged 18-35 years
* Absence of any significant medical or psychiatric disease (as per the investigators' judgment)
* Nonsmoker
* Nonpregnant
* History of normal sleep duration (reported average sleep duration between 7-9 hours/night and no habitual napping)
* Hypertension status information available for both biological parents
* Ability to understand study procedures and to comply with them for the entire length of the study
* Ability to understand English and provide informed consent

Exclusion Criteria

* Age \<18 or \>35 years
* Body mass index \<18.5 or ≥30 kg/m2
* Pregnant or lactating
* Unable to determine history of HTN in participant's biological parents or subject being adopted
* Use of tobacco, vaping, marijuana products or other drugs
* Excessive caffeine consumption (\>400 mg/day)
* Excessive alcohol consumption (\>7 drinks/week for women, \>14 drinks/week for men)
* Office SBP/DBP ≥130/80 mmHg
* Daytime ambulatory SBP/DBP ≥130/80 mmHg
* Fasting glucose ≥126 mg/dl
* Glomerular filtration rate \<60 mL/min/BSA
* History of significant medical or psychiatric disorders (as per the investigators' judgment)
* Regular use of prescription medications other than contraceptives
* Use of melatonin supplements or any other over-the-counter sleep aid
* Moderate-to-severe sleep disordered breathing (apnea/hypopnea index, AHI ≥15) or mild sleep disordered breathing (AHI 5-15) with daytime sleepiness (Epworth Sleepiness Scale \>10)
* Moderate-to-severe insomnia (Insomnia Severity Index \>14)
* Restless leg syndrome (as per the Cambridge-Hopkins questionnaire)
* Excessive daytime sleepiness (Epworth Sleepiness Scale \>15)
* Extreme chronotype (Morningness-Eveningness Questionnaire \>69 or \<31)
* Night shift work
* Ongoing participation in other research studies (as per the investigators' judgment)
* Any other medical, geographic, or social factor making study participation impractical
* Not English-speaking and/or inability to provide informed consent
* Exclusionary for blood draws: hemoglobin \<11.6 g/dL in women / \<13.2 g/dL in men; participants with measured hemoglobin levels below these thresholds will be allowed to continue participate in study tests and procedures not involving blood draws.