Home › Pain After Surgery › NCT06483659
Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy
RecruitingPhase 2Healthy volunteers welcome
Who can join
Ages 18 to 65 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Ages 18-65 years old * ASA category 1-3 * Scheduled to undergo minimally invasive hysterectomy * No documented allergy to oxytocin Exclusion Criteria: * American Society of Anesthesiologists (ASA) group 4 or greater * Age \>65 years old * Additional surgical procedures including but not limited to minor laparotomy, omentectomy, cystectomy, vaginectomy, and/or ablation of endometriosis. * Active opioid prescription of the equivalent of oxycodone \>10 mg /day * Opioid use disorder, including patients in treatment receiving naltrexone or Suboxone (Buprenorphine-naloxone) * Allergies to any study medication: acetaminophen, celecoxib, ketorolac, fentanyl, hydromorphone, or oxycodone. * Epidural/Regional anesthesia for intra-operative or post-operative pain. * Inability to understand the questionnaires * Intra-operative and post-operative exclusion: Procedure converted to open or extension of primary surgery, Intra-operative EBL \>500 ml., Placement of epidural catheter or regional anesthesia at PACU for pain management, Hospitalization of the patient due to surgical or anesthetic complications
About the study
This is a randomized, double-blinded, placebo-controlled trial to compare the effectiveness of IV oxytocin infusion to placebo on peri-operative opioid consumption and reducing post-operative pain following a minimally invasive hysterectomy under general anesthesia.
What is being tested
- Oxytocin (drug)
- Placebo (drug)
Sponsor: Brigham and Women's Hospital · Participants: 152 · Started: Jun 1, 2025
Contact the study team
- John J. Kowalczyk, MD · Phone: 617-732-8220
- Rusul I Al-Ani · Phone: 617-525-6483
Official record on ClinicalTrials.gov — NCT06483659
Locations in the U.S.
| Massachusetts | Brigham and Women's Hospital, Boston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.