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Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy

RecruitingPhase 2Healthy volunteers welcome

Who can join

Ages 18 to 65 · Women · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Ages 18-65 years old
* ASA category 1-3
* Scheduled to undergo minimally invasive hysterectomy
* No documented allergy to oxytocin

Exclusion Criteria:

* American Society of Anesthesiologists (ASA) group 4 or greater
* Age \>65 years old
* Additional surgical procedures including but not limited to minor laparotomy, omentectomy, cystectomy, vaginectomy, and/or ablation of endometriosis.
* Active opioid prescription of the equivalent of oxycodone \>10 mg /day
* Opioid use disorder, including patients in treatment receiving naltrexone or Suboxone (Buprenorphine-naloxone)
* Allergies to any study medication: acetaminophen, celecoxib, ketorolac, fentanyl, hydromorphone, or oxycodone.
* Epidural/Regional anesthesia for intra-operative or post-operative pain.
* Inability to understand the questionnaires
* Intra-operative and post-operative exclusion: Procedure converted to open or extension of primary surgery, Intra-operative EBL \>500 ml., Placement of epidural catheter or regional anesthesia at PACU for pain management, Hospitalization of the patient due to surgical or anesthetic complications

About the study

This is a randomized, double-blinded, placebo-controlled trial to compare the effectiveness of IV oxytocin infusion to placebo on peri-operative opioid consumption and reducing post-operative pain following a minimally invasive hysterectomy under general anesthesia.

What is being tested

Sponsor: Brigham and Women's Hospital · Participants: 152 · Started: Jun 1, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06483659

Locations in the U.S.

MassachusettsBrigham and Women's Hospital, Boston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.