Antidepressant Adherence for Depressed Adults in Primary Care

Inclusion Criteria:

* Penn Medicine primary care outpatients
* Clinical diagnosis of major depressive disorder
* A score of 10+ on the Patient Health Questionnaire 9 (PHQ-9)
* Age 21 to 64 years at the time of study entry
* Prescribed an antidepressant by their primary care clinician
* Express interest in taking antidepressant medication
* Own a cell phone
* Capable of using the electronic pill bottle
* English-speaking

Exclusion Criteria:

* Treated with antidepressants in the past 90 days
* Pregnant or breastfeeding
* An active substance use disorder other than nicotine
* A lifetime history of treatment for bipolar disorder or schizophrenia
* Hospital admission or emergency department visit for suicidal symptoms in the past year
* Lack capacity to provide informed consent
* Using antidepressant more than 10 days at baseline assessment