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Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease

Who can join

Ages 8 to 25 · All sexes

Inclusion Criteria:

* Aged ≥ 8 and ≤ 25 years of age at baseline
* Diagnosed with Sickle Cell Disease (HbSS, HbSC, HbS-Beta Thalassemia, and other related hemoglobinopathies)
* Receiving Medical Care at the DFCI/BCH Blood Disorders Center.
* Scored \> 9 on Patient Health Questionnaire 9-item (PHQ-9) or Generalized Anxiety Disorder (GAD)
* Able to speak English or Spanish language (for PRISM sessions)
* Able to read English or Spanish language (for completion of surveys)
* Cognitively able to participate in PRISM sessions and complete written questionnaires and surveys, as judged by the site investigator
* Willing and able to adhere to the study visit schedule and other protocol requirements

Exclusion Criteria:

\* does not meet above criteria

About the study

Adolescents and young adults with sickle cell disease (SCD) face challenges managing their illness and maintaining their well-being. This study proposes to test the feasibility and acceptability of a resilience-promoting intervention through a Collaborative Care Model. The primary goal is to determine with the resilience intervention (PRISM) is feasible and acceptable for adolescents and young adults with SCD. Exploratory outcomes include whether this intervention improves depression, anxiety, and pain interference.

What is being tested

• Collaborative Care Model (behavioral)
• Promoting Resilience in Stress Management (behavioral)

Sponsor: Boston Children's Hospital · Participants: 25 · Started: Oct 23, 2025

Contact the study team

• Abby Rosenberg, MD · Phone: 617.632.5286

Official record on ClinicalTrials.gov — NCT06555939

Locations in the U.S.

Conditions

• Sickle Cell Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.