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TBI Rehabilitation and Activation in Veterans
TBI Rehabilitation and Activation in Veterans (TRAIN-Vets)
Who can join
Ages 50 to 89 · All sexes
Full eligibility criteria
Inclusion Criteria: * Veteran, age 50-89 years * History (more than 6 months post injury) of mild or moderate TBI defined by the Ohio State University TBI Identification Method and DOD/VA Clinical Practice Guidelines for Definition of TBI * Sufficient vision and hearing to allow cognitive testing * Willingness to participate in water-based exercise program + cognitive training program for eight months * Approval of primary medical provider to participate in a water-based exercise program * Subjective cognitive complaints as evidenced by self-report * English proficiency to allow for cognitive testing * Internet connected device to participate in testing and cognitive training Exclusion Criteria: * Current severe and unstable psychiatric disorder * Diagnosis of dementia, Montreal Cognitive Assessment score less than 18, or delirium * TBI within the past 6 months * Acute illness or unstable chronic illness * Current severe cardiac disease * Severe TBI or open head injury * Inability to exercise consistently * Inability to read, verbalize understanding, and voluntarily sign the Informed Consent
About the study
This trial will evaluate the impact of a multicomponent program (TBI Rehabilitation and Activation in Veterans; TRAIN-Vets) on improving cognitive function over an 8-month trial period in older Veterans with traumatic brain injury (TBI). Older Veterans with a history of TBI and subjective cognitive complaints will be enrolled and randomly assign to either the TRAIN-Vets intervention (consisting of aquatic-based exercise training, cognitive training, and lifestyle coaching) or the Health Education Control, where they will receive educational materials about brain health and healthy lifestyles.
What is being tested
- TRAIN-Vets (behavioral)
- Health Education Control (behavioral)
Sponsor: Northern California Institute of Research and Education · Participants: 120 · Started: May 12, 2025
Contact the study team
- Carrie Peltz, PhD · Phone: 415-221-4810
- Julia Cheunkarndee · Phone: 415-221-4810
Official record on ClinicalTrials.gov — NCT06562127
Locations in the U.S.
| California | VA Palo Alto Health Care System, Palo Alto San Francisco VA Health Care System, San Francisco |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.