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Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery

The Opioid Sparing Effect of an Inter-semispinalis Plane Block on Postoperative Pain Control in Posterior Cervical Spine Surgery

Who can join

Ages 18 to 75 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Having Posterior Cervical Spine Surgery from C2 - C7, which may extend to the upper thoracic vertebrae, inclusive to T3.
* Capacity to provide informed consent

Exclusion Criteria:

* Fusion and decompression due to trauma
* Emergent procedures
* Patient is on a medication-assisted treatment, e.g., buprenorphine, naltrexone or methadone.
* There is an infection near or in the area of neck where the block will be placed.
* The patient is having a complicated surgery or a revision surgery
* Female patient with a positive pregnancy test on the day of surgery (hospital standard-of-care).
* Patient has Diabetes
* Patients who have had a prior adverse reaction to bupivacaine or dexamethasone
* Patients with Glucose-6-phosphate dehydrogenase deficiency or congenital or idiopathic methemoglobinemia

About the study

Participants who have a surgical procedure called Posterior Cervical (neck) Spine Surgery will normally need pain medication to relieve post operative pain. This usually includes opioid medications. In this study, the consented participant may receive a nerve block procedure, in addition to the pain relieving medication. There is a fifty-fifty chance to receive the nerve block. The goal is to see if the nerve block group needs less opioid medication, has lower pain scores and is discharged from the hospital sooner.

What is being tested

• Inter-semispinalis Plane Block (procedure)
• Opioids (drug)

Sponsor: Stony Brook University · Participants: 60 · Started: Feb 21, 2025

Contact the study team

• Eman Nada, MBBCH · Phone: 516-287-9118
• Darcy Halper, B.S. · Phone: 631-444-2970

Official record on ClinicalTrials.gov — NCT06570577

Locations in the U.S.

Conditions

• Pain After Surgery

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.