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Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies

Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Adults aged 18 and older
* Diagnosed with AF, frequent PVCs, or VT before age 60
* Scheduled for catheter-based AF ablation (de-novo or repeat) OR catheter-based PVC ablation OR catheter-based VT ablation
* Able to provide written, informed consent
* P/LP variant in TTN or other CM gene (cases) or identified as a genotype-negative control.

Exclusion Criteria:

* Diagnosed with a genetic CM or arrhythmia syndrome prior to ablation procedure
* VUS in 'possibly pathogenic' subgroup (control group only)
* Previous PVC or VT ablation
* LVEF \<20%
* Prosthetic mitral or aortic valve
* Contraindication to heparin
* Prior myocardial infarction

About the study

The goal of this observational study is to determine if electrophysiologic mapping and cardiac MRI can help identify patients that have genetic forms of cardiomyopathy that are at high risk for development of dangerous ventricular arrhythmias.

The investigators aim to study:

1. the prevalence and mechanism of inducible ventricular tachycardia 2. pace-mapping to define the site of origin of ventricular arrhythmias 3. voltage mapping to define low voltage scar substrate in the basal LV to determine the risk of development of ventricular arrhythmias in patients with genetic forms of cardiomyopathy.

Participants will undergo cardiac MRI before their scheduled procedure and voltage mapping during their scheduled procedure as part of data collection.

Sponsor: Vanderbilt University Medical Center · Participants: 200 · Started: Dec 13, 2023

Contact the study team

• Dakota Graherr, RN · Phone: 615-936-6069

Official record on ClinicalTrials.gov — NCT06575881

Locations in the U.S.

Conditions

• Atrial Fibrillation
• Ventricular Tachycardia
• Ventricular Premature Complexes

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.